Aspirin

Aspirin: Antithrombotic Drug and its Pharmacology

Read more about Aspirin

A person having heart disorder is more likely to take medication for the rest of life. Medicines in Heart disorders can be of many types. These can be monotherapy or a combination of different drugs. This article highlights the details of Aspirin: an Antithrombotic Drug.

ParametersDetails
Category of DrugAspirin (Acetylsalicylic Acid) is an Antithrombotic Drug. (Read more: Which are the popular Medicines prescribed for Heart Disorders?)
Mechanism of ActionAspirin inhibits the conversion of arachidonic acid to thromboxane A2 (1), which is a potent inducer of platelet aggregation. This action is helpful in the prevention of blood clots stroke, and myocardial infarction.
IndicationsAspirin is used for
1. reducing the risk of death in myocardial infarction, transient ischemic attacks, atherothrombotic cerebral infarction,
2. As prophylaxis in Arterial thromboembolism, carotid endarterectomy
StructureThumb
Molecular detailsWeight: 180.1574
Chemical Formula- C9H8O4
IUPAC Name2-acetyloxybenzoic acid
Well Known
Pharmaceutical Brands
1. ECOSPRIN- USV
2. LOPRIN- TORRENT
Available dosage forms TABLETS
Ecosprin 150 Tablet – E-Medical Point
DoseProphylaxis: 75 mg to 325 mg orally once a day or extended-release: 162 mg orally once a day or as per physicians recommendation
Pharmacokinetic properties1. Protein binding-50% to 90%
2. Major metabolites- salicylic acid, salicyluric acid, the ether or phenolic glucuronide and the ester or acyl glucuronide
3. half-life- 13 – 19 minutes
4. Excretion of salicylates -through the kidney
5. elimination- 10% to 85% in the urine
Contraindications 1. Hypersensitivity to acetylsalicylic acid
or any other NSAID
2. Children and adolescents under 16 years
3. Gastrointestinal ulceration
4. Haemophilia and other bleeding disorders
5. Not for the treatment of gout
6. Severe renal or hepatic impairment
7. Lactation.
Precautions 1. Asthma, allergic disease
2. Impaired renal or hepatic function
3. lactation
4. Pregnancy
5. Elderly
Adverse Effects 1. Generally mild and infrequent with a lower dosage
2. Gastrointestinal discomfort or nausea
3. ulceration with occult bleeding.
4. Vertigo
5. Confusion
6. Hypersensitivity Reactions
7. tinnitus
Storage conditions Store at a temperature not exceeding 30⁰C and protected from moisture.
Pregnancy Category D

Aspirin is also used as a Non-Opioid, Non-Steroidal Anti-Inflammatory Drugs. Know about Acetylsalicylic Acid or Aspirin – for Pain relief

1 thought on “Aspirin: Antithrombotic Drug and its Pharmacology”

  1. Pingback: Acetylsalicylic Acid or Aspirin - for Pain relief - PharmaCampus

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top