Acetylsalicylic Acid

Acetylsalicylic Acid or Aspirin – for Pain relief

Non-Opioid, Non-Steroidal Anti-Inflammatory Drugs

What are NSAIDs?

Acetylsalicylic Acid is a drug in the Non-steroidal anti-inflammatory drugs (NSAIDs) category. NSAIDs are a collective class of compounds widely used in several different types of indications. The drugs under this class have effects ranging from analgesic, antipyretic, anti-inflammatory, cardio-protection, with varying levels of effectiveness. Some are also being used for cancer chemoprevention. These are one of the most commonly available OTC (over the counter) drugs.

The most common of them include paracetamoldiclofenac, and aspirin. They are sometimes, also referred to as non-narcotic, non-opioid, or aspirin-like analgesics.

Acetylsalicylic Acid Drug Profile

Category of DrugAcetylsalicylic Acid is popularly known as Aspirin.
It is an Analgesics, Antipyretics, Non-Steroidal Anti-Inflammatory Drugs.
Mechanism of ActionAcetylsalicylic acid (1) binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. This agent exhibits analgesic, antipyretic, and anticoagulant properties.
Indications Acetylsalicylic Acid is used for
1. Management of mild to moderate pain
2. Pain and inflammation of rheumatoid arthritis
3. Management of pain such
as headache, acute migraine attacks, transient
musculoskeletal pain, dysmenorrhoeal pain
and for reducing fever
Molecular detailsWeight: 180.1574
Chemical Formula- C9H8O4
IUPAC Name2-acetyloxybenzoic acid
Pharmacokinetic properties 1. Protein binding-50% to 90%
2. Major metabolites- salicylic acid, salicyluric acid, the ether or phenolic glucuronide and the ester or acyl glucuronide
3. half-life- 13 – 19 minutes
4. Excretion of salicylates -through the kidney
5. elimination- 10% to 85% in the urine
Well Known
Pharmaceutical Brands
DISPRIN TABLET in HINDI की जानकारी, लाभ, कीमत ...
Available dosage forms TABLETS
Storage conditionsStore at a temperature not exceeding 30⁰C and protected from moisture.
DoseAdults- 0.3 to 0.9g, 3 to 4 times a day (max. 4g daily)
Children- not recommended under 16 years
Contraindications 1. Hypersensitivity to acetylsalicylic acid
or any other NSAID
2. Children and adolescents under 16 years
3. Gastrointestinal ulceration
4. Haemophilia and other bleeding disorders
5. Not for the treatment of gout
6. Severe renal or hepatic impairment
7. Lactation.
Precautions 1. Asthma, allergic disease
2. Impaired renal or hepatic function
3. lactation
4. Pregnancy
5. Elderly
Adverse Effects 1. Generally mild and infrequent with lower dosage
2. Gastrointestinal discomfort or nausea
3. ulceration with occult bleeding.
4. Vertigo
5. Confusion
6. Hypersensitivity Reactions
7. tinnitus
Pregnancy Category D


7 thoughts on “Acetylsalicylic Acid or Aspirin – for Pain relief”

  1. Pingback: NSAIDs: Pain Relief, Classification, Uses - PharmaCampus

  2. Pingback: Diclofenac- NSAID and its pharmacology - PharmaCampus

  3. Pingback: Mefenamic Acid- for Pain relief its Pharmacology - PharmaCampus

  4. Pingback: Paracetamol- Popular brands and Pharmacology - PharmaCampus

  5. Pingback: Aspirin: Antithrombotic Drug and its Pharmacology - PharmaCampus

  6. Pingback: Analgesic Brands: popular analgesics for Pain Relief - PharmaCampus

  7. Pingback: What is an API or Active Pharmaceutical Ingredient? > PharmaCampus

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top