Paracetamol- Popular brands and Pharmacology

Paracetamol is a potent antipyretic drug used in fever. Non-steroidal anti-inflammatory drugs (NSAIDs) are a collective class of compounds widely used in several different types of indications. The drugs under this class have effects ranging from analgesic, antipyretic, anti-inflammatory, cardio-protection, with varying levels of effectiveness. These are one of the most commonly available OTC (over the counter) drugs.

The most common of them include paracetamoldiclofenac, and aspirin. They are sometimes, also referred to as non- narcotic, non-opioid, or aspirin-like analgesics.

Category of DrugParacetamol (acetaminophen) is an Analgesics, Antipyretics, Non-Steroidal Anti-Inflammatory Drugs
Mechanism of ActionParacetamol is a weak inhibitor (1) of the synthesis of prostaglandins.
Indications Paracetamol is used for
1. Mild to moderate pain
2. Pain relief in osteoarthritis
3. Pyrexia including post-immunization pyrexia
4. Acute migraine attack
Well Known
Pharmaceutical Brands
Crocin 650 mg tablets 10 tablets GlaxoSmithKline Paracetamol 650mg ...
Available dosage forms1. TABLETS
Dose1. Adult- 0.5 to 1 g every 4 to 6 h (max. 4g/day
2. Children
a. 3 month to 1 year: 60 to 120
mg every 4 to 6 h
b. 1 to 5 years: 120 to 250 mg
every 4 to 6 h
c. 6 to 12 years: 250 to 500 mg
every 4 to 6 h
Molecular details Molecular Formula- C8H9NO2 
Molecular Weight-151.16 g/mol
IUPAC NameN-(4-hydroxyphenyl)acetamide
Structure Thumb
Pharmacokinetic properties (2)1. 88% oral bioavailability
2. Vd-0.9L/kg
3. 10 to 20% of the drug is bound to RBCs
4. protein binding- 10% to 25%
5. metabolism pathways: conjugation with glucuronide, conjugation with sulfate, and oxidation through the cytochrome P450 enzyme
6. mainly excreted in the urine
7. half-life -2.5 h 
Contraindications1. acute liver failure.
2. liver problems
3. severe renal impairment
Precautions1. Hepatic impairment
2. Renal impairment
3. Alcohol dependence
4. Pregnancy
5. Lactation
Adverse Effects1. Rare but rashes and blood disorders reported
2. Liver damage
Pregnancy Category B

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