Mefenamic Acid

Mefenamic Acid- Pharmacology and Popular Brands

Mefenamic Acid is an Analgesic, Antipyretic, and used in the treatment of rheumatoid arthritis, osteoarthritis. Non-steroidal anti-inflammatory drugs (NSAIDs) are a collective class of compounds widely used in several different types of indications. The drugs under this class have effects ranging from analgesic, antipyretic, anti-inflammatory, cardio-protection, with varying levels of effectiveness. These are one of the most commonly available OTC (over the counter) drugs.

The most common of them include paracetamoldiclofenac, and aspirin. They are sometimes, also referred to as non- narcotic, non-opioid, or aspirin-like analgesics.

ParametersDetails
Category of DrugMefenamic Acid is an Analgesics, Antipyretics, Non-Steroidal Anti-Inflammatory Drugs
Mechanism of ActionMefenamic acid binds the prostaglandin synthetase receptors (1) COX-1 and COX-2. These receptors have a role as a significant mediator of inflammation. This, by inhibiting these receptors, the symptoms of pain are temporarily reduced.
Indications
1. Treatment of rheumatoid arthritis
2. Osteoarthritis
3. Dysmenorrhea is mild to moderate pain
4. Inflammation
5. Fever dental pain
Well Known
Pharmaceutical Brands
MEFTAL- BLUE CROSS
MEFANORM-SERUM INSTITUTE
MEFKIND-P- MANKIND
IBUCLIN-P- DR REDDYS
MEFAST- EMCURE
Available dosage forms 1. TABLETS
2. CAPSULES
3. SUSPENSION
Storage conditions Store protected from light and moisture
DoseInitial dose: 500 mg orally
Maintenance dose- 250 mg every 6 hours (SOS)
Structure (2)Thumb
Molecular details1. Molecular Weight- 241.28 g/mol
2. Molecular Formula- C15H15NO2
IUPAC Name2-(2,3-dimethylanilino)benzoic acid
Pharmacokinetic properties 1. Absorption- is rapidly absorbed after oral administration.
2. Volume of distribution- 1.06 L/kg 3. Protein binding- 90%
4. Route of elimination- The fecal route
5. Half-life- 2 hours
6. Clearance=21.23 L/hr 
Contraindications1. Known hypersensitivity to mefenamic acid
2. Patients who have experienced asthma
3. Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
5. Active ulceration or chronic inflammation of the gastrointestinal tract
6. Interactions
Precautions1. Hepatic effects
2. Anaemia
3. Asthma
Adverse Effects 1. Gastrointestinal experiences
2. bronchospasm,
3. anemia,
4. dizziness,
5. edema
Pregnancy Category C

Read more

  1. Rheumatoid arthritis
  2. NSAIDs: Pain Relief, Classification, Uses
  3. Analgesic Brands: popular analgesics for Pain Relief
  4. Diclofenac- NSAID and its pharmacology
  5. Acetylsalicylic Acid or Aspirin- drug details

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