Heparin- Indications, Dosage, Contraindications, ADRs

Category of Drug Heparin is a Drug Affecting Coagulation
Mechanism of Action 
Indications Heparin is used for
1. Treatment and prophylaxis of deep-vein thrombosis and pulmonary embolism
2. Atrial fibrillation with embolism
3. Treatment and prophylaxis of peripheral arterial embolism
4. Prophylaxis of deep vein thrombosis in major
5. Lipemia clearing
Well Known
Pharmaceutical Brands
Available dosage forms INJECTION
Contraindications 1. Hypersensitivity to heparin
2. Haemophilia and other haemorrhagic disorders
3. Thrombocytopenia
4. Peptic ulcer
5. Recent cerebral haemorrhage
6. Severe hypertension
7. Severe liver or renal disease
8. After major trauma or recent surgery
9. Lumbar puncture
10. Chronic alcoholics
11. Acetylsalicylic acid and other
antiplatelet drugs
Precautions 1. Hepatic impairment
2. Renal failure
3. Hypersensitivity to low molecular weight heparins
4. Spinal or epidural anaesthesia-risk of spinal haematoma;
5. Diabetes Mellitus
6. Acidosis
7. Concomitant potassium-sparing drugs-increased risk of hyperkalaemia
8. Lactations
9. Pregnancy
10. Interactions
11. Paediatrics
12. Elderly
Adverse Effects 1. Immune-mediated thrombocytopenia usually
developing 6 to 10 days after commencement of therapy
2. Haemorrhage
3. Skin necrosis
4. Hypersensitivity reactions
5. osteoporosis after prolonged use
6. Alopecia
7. Bleeding due to overdose
Pregnancy Category C

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