Phytomenadione- Indications, Dosage, Contraindications, ADRs

Category of Drug Phytomenadione is a Drug Affecting Coagulation
Mechanism of Action 
Indications Phytomenadione is used for
1. Antagonist to warfarin
2. Prophylaxis against
the haemorrhagic disease of the newborn
3. Vit K deficiency
4. Hematuria
5. Menorrhagia
Well Known
Pharmaceutical Brands
Available dosage forms 1. TABLETS
Contraindications Hypersensitivity
Precautions 1. Reduce dose in elderly
2. Hepatic impairment
3. Not an antidote to heparin
5. Can cause haemolysis in patients with G-6-PD
6. Increased risk of severe haemolytic anaemia in neonates after large doses
7. Premature neonates weighing < 2.5 kg
8. Pregnancy
Adverse Effects 1. Hypersensitivity reactions
2. Hypotension and respiratory or
a circulatory collapse which may be due to polyethoxylated castor oil surfactant in some
injection formulations rather than due to phytomenadione
Pregnancy Category C

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