Dextran 40

Dextran 40- Indications, Dosage, Contraindications, ADRs

Category of Drug Dextran 40 is Blood Products and Plasma Substitutes
Mechanism of Action 
Indications Dextran 40 is used for
1. Plasma volume expansion during hypovolemic shock when blood not available
2. Prophylaxis of thromboembolic disorders to improve local circulation in peripheral vascular occlusion
Well Known
Pharmaceutical Brands
Available dosage forms INFUSION
Contraindications 1. Hypersensitivity
2. Cardiac decompensation
3. Oliguria or anuria
4. Hemostatic defects
5. Thrombocytopenia
6. Blood coagulation disorder
7. Pulmonary oedema
8. Neonates
Precautions 1. Renal and hepatic impairment
2. Pregnancy
3. lactation
4. Diabetes
5. Cardiac patients
6. Elderly
7. Monitor urine output
8. Monitor for signs of circulatory overload
9. Interactions
Adverse Effects 1. Nausea
2. Voming
3. Local injection site reaction
4. Hypersensitivity and anaphylactoid reactions
5. Increased serum SGOT and SGPT concentrations
6. Osmotic nephrosis
Pregnancy Category C

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