Alteplase- Indications, Dosage, Contraindications, ADRs

Category of DrugAlteplase is an Antithrombotic Drug
Mechanism of Action 
Indications Alteplase is used for
1. Acute myocardial infarction
2. Acute massive pulmonary embolism
3. Acute ischaemic
Well Known
Pharmaceutical Brands
Available dosage forms INJECTION
Contraindications 1. Uncontrolled hypertension with possible cerebrovascular haemorrhage
2. Recent surgery or trauma
3. Susceptibility to internal
4. Uncontrolled hypertension
5. Esophageal varices
6. Heavy vaginal bleeding
7. Bleeding diathesis
8. active peptic ulceration
Precautions 1. Monitor for bleeding and BP in acute stroke
2. Caution in recent surgery or invasive procedures
3. Diabetic hemorrhagic
4. Severe hepatic and renal
5. Pregnancy
6. lactation
7. Children
8. Elderly
9. Interactions
Adverse Effects 1. Haemorrhage including intracranial
2. Gastrointestinal or genitourinary bleeding
3. Transient hypotension
4. Reperfusion
5. Dysrhythmias
6. Cerebral edema
7. Seizures
8. Allergic-type reactions
9. Nausea
10. Vomiting
Pregnancy Category C

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