Drug

Category of Drug  Azathioprine is Immunosuppressives Drug Mechanism of Action   Indications  Azathioprine is used 1. To prevent rejection in transplant recipients2. Rheumatoid arthritis3. Inflammatory bowel disease4. Multiple sclerosis5. Autoimmune hepatitis6.Atopic dermatitis (AD) Well KnownPharmaceutical Brands   Available dosage forms  TABLETS Dose   Contraindications  1. Hypersensitivity to azathioprine and mercaptopurine2. lactation Precautions  1. Monitor for toxicity […]

Parameters Description Category of Drug Doxorubicin is part of the anthracycline group of chemotherapeutic agents. Mechanism of Action (1) Doxorubicin causes the breakage of DNA strands and inhibits both DNA and RNA synthesis. Doxorubicin inhibits the enzyme topoisomerase II, causing DNA damage and induction of apoptosis. When combined with iron, doxorubicin also causes free radical-mediated

Parameters Details Category of Drug Cytosine Arabinoside (Cytarabine) is an antineoplastic anti-metabolite Mechanism of Action Cytarabine acts by interfering with DNA synthesis. Cytarabine is cytotoxic and acts through the inhibition of DNA polymerase. It exhibits cell phase specificity, blocking cells’ progression from the G1 phase to the S-phase. Indications  Cytosine Arabinoside (Cytarabine) is used for1.

Parameters Details Category of Drug Cyclophosphamide is an alkylating agent Mechanism of Action Cyclophosphamide is an activated form of cyclophosphamide and acts as an alkylating agent. It binds to DNA. It produces a cytotoxic effect by cross-linking strands of DNA and RNA. Cyclophosphamide is known to inhibit protein synthesis. (3) Indications Cyclophosphamide is used for

Parameter Details Category of Drug Cisplatin (Alkylating agent) is a platinum-based chemotherapy drug and Immunosuppressives Drug Mechanism of Action (1) 1. The alkyl groups attach to DNA bases, preventing DNA synthesis and RNA transcription from the affected DNA. 2. The formation of cross-links causes DNA damage which prevents DNA from being separated for synthesis or transcription, 3.

Category of Drug  Chlorambucil is Immunosuppressives Drug Mechanism of Action   Indications  Chlorambucil is used for1. Chronic lymphocytic leukaemia2. Some of non-Hodgkin’s lymphomas3. Hodgkin’s disease4. Ovarian cancer5. Waldenstrom (primary)macroglobulinaemia Well KnownPharmaceutical Brands   Available dosage forms  TABLETS Dose   Contraindications 1. Hypersensitivity2. Porphyria3. Pregnancy4. lactation Precautions 1. Renal impairment2. Hepatic impairment Adverse Effects  1. Hepatotoxicity2. Peripheral neuropathy3. Cystitis4.

Category of Drug  Busulphan is Immunosuppressives Drug Mechanism of Action   Indications  Busulphan is used for1. Chronic granulocytic leukaemia2. Chronic myelogenous leukaemia3. Polycythaemia vera4. Myelofibrosis5. Thrombocythaemia Well KnownPharmaceutical Brands   Available dosage forms  TABLET Dose   Contraindications  1. Pregnancy 2. Bone marrow suppression3. Chronic lymphocytic leukaemia4. Lactation Precautions  1. Monitor cardiac function2. Pregnancy3. lactation previous radiation

Category of Drug  Bleomycin is Immunosuppressives Drug Mechanism of Action   Indications  Bleomycin is used for 1. Adjunct to surgery and radiotherapy in the palliative treatment of Hodgkin’s andnon-Hodgkin’s lymphomas2. Reticulum cell sarcoma and lymphoma3. Embryonal cell carcinoma4. Choriocarcinoma and teratoma5. Malignant effusions Well KnownPharmaceutical Brands   Available dosage forms  INJECTION Dose   Contraindications  1. lung

Category of Drug Alpha Interferon is  Immunosuppressives Drug Mechanism of Action   Indications  Alpha Interferon is used for1. Hairy cell leukaemia2. AIDS-related Kaposi’ssarcoma in patients above 18 years3. Malignant melanoma Well KnownPharmaceutical Brands   Available dosage forms  VIALS Dose   Contraindications  1. Consult product literature 2. Avoid injections containing benzyl alcohol in neonates3. Pregnancy4. Lactations Precautions

Parameters Details Category of Drug Actinomycin D is an Antineoplastic antibiotic drug. Mechanism of Action  It binds strongly, but reversibly, to DNA, interfering with the synthesis of RNA. Thus, it prevents RNA polymerase elongation and, consequently, inhibits protein synthesis. Indications Actinomycin D is used for1. Trophoblastic tumors2. Wilm’s tumor3. Ewing’s sarcoma4. Rhabdomyosarcoma Synonyms Actinomycin IChounghwamycin