Actinomycin D

Actinomycin D- Indications, Dosage, Contraindications, ADRs

Category of DrugActinomycin D is an Antineoplastic antibiotic drug.
Mechanism of Action It binds strongly, but reversibly, to DNA, interfering with the synthesis of RNA. Thus, it prevents RNA polymerase elongation and, consequently, inhibits protein synthesis.
IndicationsActinomycin D is used for
1. Trophoblastic tumors
2. Wilm’s tumor
3. Ewing’s sarcoma
4. Rhabdomyosarcoma
SynonymsActinomycin I
Chounghwamycin B
Actinomycin A-IV
Structure (1)Actinomycin D.png
IUPAC Name2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Molecular details Molecular Formula- C62H86N12O16
Molecular Weight- 1255.4 g/mol
Well Known
Pharmaceutical Brands
1. Absorption- poorly absorbed from the GI tract.
2. Plasma protein binding- 5%.
3. Slightly metabolized
4. plasma half-life – 36 hours
5. elimination half-life- 36 to 48 hours.
Available dosage forms INJECTION
Actinomycin (Generic Dactinomycin) - Prescriptiongiant
Dose Adult and child above 6 months- 15 μg/kg/day.
Contraindications1. Hypersensitivity
2. lactation
3. Infection with children
4. Herpes zoster
5. Pregnancy
Adverse Effects  1. Hair loss
2. Nausea
3. Vomiting
4. Mouth sores
5. Diarrhoea
Pregnancy Category D

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