|Category of Drug||Cisplatin (Alkylating agent) is a platinum-based chemotherapy drug and Immunosuppressives Drug|
|Mechanism of Action (1)||1. The alkyl groups attach to DNA bases, preventing DNA synthesis and RNA transcription from the affected DNA.|
2. The formation of cross-links causes DNA damage which prevents DNA from being separated for synthesis or transcription,
3. Mutation is caused due to the mispairing of the nucleotides
|Molecular details||Weight: 300.05|
Chemical Formula- Cl2H6N2Pt
|Indications|| Cisplatin is used for|
1. Metastatic testicular tumors
2. Metastatic ovarian tumors (3)
3. Advanced bladder carcinoma and other solid tumors
| 1. Absorption- concentrations of platinum are highest in the liver, prostate, and kidney; it remains present in tissues as long as 180 days after the last administration.|
Volume of distribution
2. Vd = 11-12 L/m^2
3. Protein binding- 90% of the plasma platinum is protein bound.
4. Metabolism- NA
5. Route of elimination- Major part excreted in the urine.
6. Half-life- 20 to 30 minutes
|KEMOPLAT- FRESENIUS KABI|
CELPLAT- CELON LAB
CIZCAN- NEON LABS
CISPLAT- ZYDUS CADILA
|Available dosage forms|| INJECTION|
|Dose||1. Ovarian tumor: 50 mg/m2 of body surface area once every three weeks. 2. 2. 2. Bladder cancer:|
50 to 70 mg/m2 once every 3 to 4 weeks.
3. Testicular tumor: 20 mg/m2 for 5 days every 3 weeks for 3 courses.
2. Renal impairment
|Adverse Effects||1. Tinnitus|