Cyclophosphamide- an Alkylating Agent to treat Cancer

Category of DrugCyclophosphamide is an alkylating agent
Mechanism of ActionCyclophosphamide is an activated form of cyclophosphamide and acts as an alkylating agent. It binds to DNA. It produces a cytotoxic effect by cross-linking strands of DNA and RNA. Cyclophosphamide is known to inhibit protein synthesis. (3)
IndicationsCyclophosphamide is used for
1. Malignant lymphomas
2. Lymphocytic lymphoma
3. Burki’s lymphoma
4. Multiple myeloma
5. Leukaemias
6. Mycosis fungoides
7. Neuroblastoma
8. Adenocarcinoma of the
ovary (1)
9. Retinoblastoma
10. Breast cancer (2)
Well Known
Pharmaceutical Brands
Available dosage formsIntravenous injection
Cyclophosphamide Injection, 500mg, Rs 8 /bottle Bramh Chaitanya  Medicalstore | ID: 21974830433
DoseMalignancy: 40 to 50 mg/kg body weight in divided doses over 2 to 5 days. Alternatively 10 to 15 mg/kg body weight every 7 to 10 days
or 3 to 5 mg/kg body weight twice a week.
Contraindications 1. Bladder haemorrhage
2. Thrombocytopenia;
3. Severe bone marrow depression
4. Pregnancy
Precautions1. Renal impairment
2. Hepatic impairment
3. Interactions
Adverse Effects1. Haemorrhagic cystitis
2. Colitis
3. Cardiac toxicity
4. Anorexia
5. Thrombocytopenia
6. Dermatitis
Pregnancy Category D

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