| Parameters | Details |
|---|---|
| Category of Drug | Cyclophosphamide is an alkylating agent |
| Mechanism of Action | Cyclophosphamide is an activated form of cyclophosphamide and acts as an alkylating agent. It binds to DNA. It produces a cytotoxic effect by cross-linking strands of DNA and RNA. Cyclophosphamide is known to inhibit protein synthesis. (3) |
| Indications | Cyclophosphamide is used for 1. Malignant lymphomas 2. Lymphocytic lymphoma 3. Burki’s lymphoma 4. Multiple myeloma 5. Leukaemias 6. Mycosis fungoides 7. Neuroblastoma 8. Adenocarcinoma of the ovary (1) 9. Retinoblastoma 10. Breast cancer (2) |
| Well Known Pharmaceutical Brands | ENDOXAN-ZYDUS CADILA |
| Available dosage forms | Intravenous injection |
| Dose | Malignancy: 40 to 50 mg/kg body weight in divided doses over 2 to 5 days. Alternatively 10 to 15 mg/kg body weight every 7 to 10 days or 3 to 5 mg/kg body weight twice a week. |
| Contraindications | 1. Bladder haemorrhage 2. Thrombocytopenia; 3. Severe bone marrow depression 4. Pregnancy |
| Precautions | 1. Renal impairment 2. Hepatic impairment 3. Interactions |
| Adverse Effects | 1. Haemorrhagic cystitis 2. Colitis 3. Cardiac toxicity 4. Anorexia 5. Thrombocytopenia 6. Dermatitis |
| Pregnancy Category | D |
