Azathioprine- Indications, Dosage, Contraindications, ADRs

Category of Drug Azathioprine is Immunosuppressives Drug
Mechanism of Action 
Indications Azathioprine is used
1. To prevent rejection in transplant recipients
2. Rheumatoid arthritis
3. Inflammatory bowel disease
4. Multiple sclerosis
5. Autoimmune hepatitis
6.Atopic dermatitis (AD)
Well Known
Pharmaceutical Brands
Available dosage forms TABLETS
Contraindications 1. Hypersensitivity to azathioprine and mercaptopurine
2. lactation
Precautions 1. Monitor for toxicity throughout treatment
2. Full blood counts necessary every week
3. Reduce dose in elderly
4. Renal impairment
5. Liver disease
6. Interactions
7. lactation
8. Pregnancy
Adverse Effects 1. Hypersensitivity reaction
2. Rash
3. Hypotension or interstitial
nephritis call for immediate withdrawal
4. Haematological toxicity
5. Thrombocytopenia
6. Liver impairment
7. Cholestatic jaundice
8. Hair loss
9. nausea
10. Pancreatitis
11. Pneumonitis
Pregnancy Category D

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top