Busulphan- Indications, Dosage, Contraindications, ADRs

Category of Drug Busulphan is Immunosuppressives Drug
Mechanism of Action 
Indications Busulphan is used for
1. Chronic granulocytic leukaemia
2. Chronic myelogenous leukaemia
3. Polycythaemia vera
4. Myelofibrosis
5. Thrombocythaemia
Well Known
Pharmaceutical Brands
Available dosage forms TABLET
Contraindications 1. Pregnancy
2. Bone marrow suppression
3. Chronic lymphocytic leukaemia
4. Lactation
Precautions 1. Monitor cardiac function
2. Pregnancy
3. lactation previous radiation therapy
4. Avoid in porphyria
5. Hepatic impairment
6. Interactions
Adverse Effects 1. Hepatotoxicity
2. Cardiac tamponade at high doses in thalassaemic patients
3. Pneumonia
4. Skin hyperpigmentation
5. Hyperuricemia
6. Pulmonary fibrosis
Pregnancy Category D

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