Famotidine

Famotidine-Pharmacology and popular brands

Histamine receptor blockers inhibit gastric acid secretion, particularly effective against nocturnal acid secretion. They block histamine binding to H2 receptors competitively, leading to decreased intracellular signaling molecules for gastric acid release, in turn decreasing the secretion. Famotidine decreases stomach acid production.

Antacids are only employed for intercurrent pain relief and acidity and are self-prescribed by the patients. The antacids are used for providing symptomatic relief from Gastroesophageal reflux disease (GERD), acid eructation, and heartburn.

ParametersDetails
Category of DrugHistamine receptor blockers
Mechanism of ActionFamotidine decreases stomach acid production.
Indications1. Duodenal or benign gastric ulcers
2. GERD
3. Zollinger-Ellison syndrome
StructureThumb
Molecular details1. Molecular Formula- C8H15N7O2S3
2. Molecular Weight- 373.9 g/mol
IUPAC Name3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N‘-sulfamoylpropanimidamide;hydron;chloride
Well Known
Pharmaceutical Brands
1. FAMOCID- SUN
2. FAMTAC- ABBOTT
3. TOPCID- TORRENT PHARMA
4. FACID- INTAS
5. FAMONEXT- CADILA
Available dosage forms1. TABLETS
2. CAPSULES
3. INJECTION
Dose1. 40 mg orally once a day
2. 20 mg orally 2 times a day
Pharmacokinetic properties1. The oral bioavailability-40-50%, 2. Cmax -1-4 hours
3. Vd- 1.0 to 1.3 L/kg
4. The protein binding-15 to 22%.
5. elimination- 25-30% through hepatic metabolism.
6. metabolite- S-oxide
7.  half-life -2 to 4 hours
Storage conditions1. Store protected from light,
2. Injection to be stored between 2-8⁰C
ContraindicationsHypersensitivity
Precautions1. Gastric malignancy
2. Impaired renal function
3. liver cirrhosis
4. Pregnancy
5. lactation
Adverse Effects1. Headache
2. dizziness
3. constipation
4. diarrhea
5. nausea
6.vomiting
7.anorexia
8. rash
9.fatigue
10.gynaecomastia
11. impotence
Pregnancy Category B

References

  1. Gastroenterology: Which are the popular Brands?
  2. Ulcers in the stomach- How is it treated?
  3. Digestive system: What is the Structure and Function?
  4. Aluminium Hydroxide: Pharmacology and brands
  5. Magnesium Hydroxide- Drug Detail Profile
  6. MOA of famotidine
  7. famotidine brands
  8. famotidine dosage

1 thought on “Famotidine-Pharmacology and popular brands”

  1. Pingback: Antacids and Antiulcer Drugs: Classification - PharmaCampus

Leave a Comment

Your email address will not be published. Required fields are marked *