As the name indicates, antacids are ‘anti-acids.’ Chemically, the drugs of this class are basic compounds that aid in neutralizing the released gastric acid and raise the pH of gastric contents. Under this condition, pepsin activity gets reduced if the pH rises above 4; since pepsin gets secreted as a complex with an inhibitory terminal part that dissociates below pH 5. The optimum peptic activity is in the pH 2 to 4. This article explains the pharmacology of Aluminium Hydroxide.
Aluminum hydroxide gel (Aldurox tab.)– It is a slow-reacting, bland, and weak antacid. When stored for a long time, it polymerizes into lesser reactive forms. Thus, the ANC of any aluminum hydroxide preparation declines gradually.
|Category of Drug||Aluminium Hydroxide is an Antacid|
|Mechanism of Action||1. Aluminum hydroxide acts by neutralizing hydrochloric acid in gastric secretions. |
2. It increases pH, thus may inhibit the action of pepsin.
|Molecular details||1. Molecular Formula- AlH3O3 or Al(OH)3|
2. Molecular Weight- 78.004 g/mol
|IUPAC Name||aluminum tri-hydroxide|
2. Non-ulcer dyspepsia
|1. MUCAINE GEL (PFIZER)- ALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE + OXETACAINE|
2. GELUSIL-MPS (PFIZER)- ALUMINIUM HYDROXIDE + DIMETICONE + MAGNESIUM HYDROXIDE
|Storage conditions||1. Protect from moisture |
2. Do not exceed temp. 30⁰C.
3. Do not freeze Gel
|Available dosage forms||1. Tablet|
|Dose||Adults: 1 to 2 tablets; 4 times daily or 5 to 10 ml suspension four times daily|
Kids: 5 ml suspension three times daily
2. Undiagnosed gastrointestinal
5. Hypersensitivity to aluminum salts
|Precautions||1. Impaired renal function |
2. hepatic impairment
5. Gastrointestinal disorders
6. Cirrhosis and low sodium diets
|Adverse Effects||1. Constipation, |
4. hyper albuminemia
6. loss of appetite
|Pregnancy Category||Category C|