Aluminium Hydroxide

Aluminium Hydroxide: Pharmacology and brands

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As the name indicates, antacids are ‘anti-acids.’ Chemically, the drugs of this class are basic compounds that aid in neutralizing the released gastric acid and raise the pH of gastric contents. Under this condition, pepsin activity gets reduced if the pH rises above 4; since pepsin gets secreted as a complex with an inhibitory terminal part that dissociates below pH 5. The optimum peptic activity is in the pH 2 to 4. This article explains the pharmacology of Aluminium Hydroxide.

Aluminum hydroxide gel (Aldurox tab.)– It is a slow-reacting, bland, and weak antacid. When stored for a long time, it polymerizes into lesser reactive forms. Thus, the ANC of any aluminum hydroxide preparation declines gradually.

ParametersDetails
Category of DrugAluminium Hydroxide is an Antacid
Mechanism of Action1. Aluminum hydroxide acts by neutralizing hydrochloric acid in gastric secretions.
2. It increases pH, thus may inhibit the action of pepsin.
Molecular details1. Molecular Formula- AlH3O3 or Al(OH)3
2. Molecular Weight- 78.004 g/mol
IUPAC Namealuminum tri-hydroxide
StructureThumb
Indications1. Ulcer
2. Non-ulcer dyspepsia
3. GERD
4. hyperphosphataemia
Well Known
Pharmaceutical Brands
1. MUCAINE GEL (PFIZER)- ALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE + OXETACAINE
2. GELUSIL-MPS (PFIZER)- ALUMINIUM HYDROXIDE + DIMETICONE + MAGNESIUM HYDROXIDE
TAB GELUSIL | INTELLECT WELLNESS CHEMIST PVT. LTD.
Storage conditions1. Protect from moisture
2. Do not exceed temp. 30⁰C.
3. Do not freeze Gel
Available dosage forms1. Tablet
2. Suspension
3. Gel
4. Syrup
DoseAdults: 1 to 2 tablets; 4 times daily or 5 to 10 ml suspension four times daily

Kids: 5 ml suspension three times daily
Contraindications1. Hypophosphataemia
2. Undiagnosed gastrointestinal
bleeding
3. Appendicitis
4. porphyria
5. Hypersensitivity to aluminum salts
Precautions1. Impaired renal function
2. hepatic impairment
3. Constipation
4. Dehydration
5. Gastrointestinal disorders
6. Cirrhosis and low sodium diets
Adverse Effects1. Constipation,
2. hypophosphatemia
3. hypercalciuria
4. hyper albuminemia
5. Encephalopathy
6. loss of appetite
Pregnancy CategoryCategory C

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