Magnesium Hydroxide

Magnesium Hydroxide- Drug Detail Profile

Magnesium hydroxide (Milk of Magnesia-antacid) is used as adjunctive therapy to reduce the damage during acid secretion. It provides symptomatic relief and does not cure the cause. Antacids do not decrease acid production but raise the pH more than 4.

The potency of an antacid is expressed in terms of its acid-neutralizing capacity (ANC). ANC takes into consideration the rate at which the antacid dissolves and reacts with HCL in the stomach. The drugs under these can thus be differentiated based on their ANC, which helps determine the dosing regimen. This is significant because a single dose of any antacid taken in an empty stomach acts for 30–60 minutes, as the gastric content passes into the duodenum. Antacids may act for a period of 2–3 hours if taken along with meals.

ParametersDetails
Category of DrugMagnesium Hydroxide is used Antacids and Antiulcer Drugs
Mechanism of ActionMagnesium Hydroxide acts by neutralizing hydrochloric acid in gastric secretions. It increases pH, thus may inhibit the action of pepsin.
StructureThumb
Molecular details1. Molecular Formula- H2MgO2
2. Molecular Weight- 58.32 g/mol
IUPAC Namemagnesium; dihydroxide
1. Absorption- About 15%-50%
2. does not have any protein binding
3. mainly excreted in the urine
Indications Magnesium Hydroxide is used in
1. Ulcer and non-ulcer dyspepsia
2. GERD
Well Known
Pharmaceutical Brands
1. GELUSIL-MPS-PFIZER
2. CREMAFFIN- ABBOTT
3. DEY’S MILK MAGNESIA- DEY’S
4. MILK OF MAGNESIA- SIRI
Cremaffin Plus Syrup - Uses, Side Effects, Dosage, Price - JustDoc
Available dosage forms 1. TABLET
2. SUSPENSION
DoseAdult- Dyspepsia, GERD: 5 to 10 ml repeated
according to the patient’s needs.
Contraindications  Severe renal impairment
Precautions1. Renal impairment
2. Hepatic impairment
3. Interactions
4. Abdominal pain
Adverse Effects 1. Diarrhoea
2. Renal impairment
Pregnancy Category B

References

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