Parameters | Details |
---|---|
Category of Drug | Omeprazole is Antacids and Anulcer Drugs (1) |
Mechanism of Action | Omeprazole is a proton pump inhibitor. It inhibits the parietal cell H+ / K+ ATP pump, the final step of acid production. (2) |
Indications | Omeprazole is used in 1. Benign gastric and duodenal ulcers 2. Zollinger 3. Ellison syndrome 4. gastric Acid Reduction during gastric surgery 5. GERD 6. NSAID- induced ulcer 7. Prophylaxis during NSAIDs treatment in patients with high risk for peptic ulceration 8. Eradication of H.pylori, as preoperative medication 9. Systemic mastocytosis and in patients not responsive to H2 blockers. |
Well Known Pharmaceutical Brands | OMEZ- DR. REDDY’S LABS OCID- ZYDUS CADILA OMEY- INTAS PHARMA ![]() |
Available dosage forms | 1. TABLETS 2. INJECTION 3. CAPSULES |
Dose | 20 mg OD for 4 weeks in duodenal ulcers, for 8 weeks in gastric ulcers, Increase to 40 mg in severe cases. |
Contraindications | Hypersensitivity |
Precautions | 1. Interactions 2. Pregnancy 3. Concomitant gastric 4. Malignancy |
Adverse Effects | 1. Nausea 2. Abdominal pain 3. Constipation 4. Flatulence 5. Diarrhoea 6. Headache 7. Skin 8. Rashes 9. Subacute 10. Myopathy 11. Arthralgias 12. Increased risk of hip fractures 13. Decreased B12 absorption 14. Hypergastrenemia 15. Respiratory 16. Clostridium difficile infections 17. hepatic dysfunction. |
Pregnancy Category | C |

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