medicines for viral infections

Which are the popular medicines prescribed for viral infections?

viral infection is caused due to the growth of a harmful virus inside the body. Viruses need a host to reproduce and thus need to infect the body of the host. Viruses introduce their genetic material into the host cells and multiply to make more virus particles. Antiviral drugs are medicines for viral infections. This article highlights medicines for viral infections

Commonly Prescribed Antiviral drugs

acyclovir

Acyclovir: It gets converted to acyclovir monophosphate by viral thymidine kinase and then undergoes a series of reactions by various enzymes to form acyclovir triphosphate. This form is more selective to the viral DNA polymerase than the cellular DNA and gets incorporated into the former resulting in viral DNA chain termination.

atazanavir

Atazanavir: It binds to the active site of HIV – 1 protease and forms an enzyme – inhibitor complex that inhibits virus-specific processing of viral Gag and Gag Pol polyproteins. These in turn prevent the formation of mature infection virions. This antiviral agent is inactive against HIV – 2 protease.  

ritonavir

Ritonavir : It inhibits HIV protease and prevents the cleavage of the polyproteins by these enzymes. This in turn blocks the formation of mature virions in the initial stage itself. At low doses, this agent inhibits Cytochrome P450 – 3A4 and this in turn enhances the activity of the other protease inhibitors with which it is used in combination.

Dolutegravir

Dolutegravir : It binds to and inhibits HIV integrase to block the transfer of strand from the retroviral DNA to the host cell. This in turn inhibits viral replication and activity.

Lamivudine

Lamivudine : It is a nucleoside reverse transcriptase inhibitor and competitively inhibits HIV reverse transcriptase enzyme and acts as a chain terminator of viral DNA synthesis. The drug is phosphorylated to form lamivudine metabolites that compete to get incorporated into the viral DNA to elicit the action. It also inhibits the reverse transcriptase of hepatitis – B virus.

Tenofovir

Tenofovir : It gets phosphorylated to form the active form and then inhibits viral reverse transcriptase by competing with deoxyadenosine – 5’ – triphosphate. It also causes premature termination of DNA transcription and prevents viral replication.

Efavirenz

Efavirenz : It binds to and inhibits reverse transcriptase in a non-competitive manner. This in turn inhibits the polymerization of viral DNA from the corresponding RNA and thereby prevents the synthesis of new virions.

Emtricitabine

Emtricitabine: It gets converted to the active triphosphate form intracellularly and competes with deoxycytidine– 5’ – triphosphate for incorporation into the viral DNA strand. This in turn causes DNA chain termination and inhibits viral DNA synthesis.

Entecavir : It gets activated invivo to form the triphosphate metabolite that competes with the deoxyguanosine triphosphate, a natural substrate, for incorporation into the viral DNA. It inhibits reverse transcriptase, viral RNA dependent HBV BNA polymerase and thereby stops viral replication.

Oseltamivir

Oseltamivir : It is a prodrug of oseltamivir carboxylate that selectively inhibits influenza virus neuramidinase enzymes. It inhibits viral entry into uninfected cells, reduces viral shedding and activity.

Sofosbuvir

Sofosbuvir : The active phosphorylated form gets incorporated into the Hepatitis C virus RNA by the NS5B ( Non structural protein 5B) polymerase. This in turn inhibits viral RNA synthesis and induces chain termination.

Velpatasvir

Velpatasvir : It is a selective NS5A inhibitor and competes with RNA for binding to the domain 1 of Hepatitis C virus NS5A protein. This in turn inhibits viral replication.

Valacyclovir

Valacyclovir : It gets metabolized to form acyclovir initially and this in turn gets converted to the active triphosphate form by a series of reactions. The triphosphate form competitively inhibits and inactivates the viral DNA polymerase by getting incorporated into the growing viral DNA chain.

Now, let us review the popularly prescribed brands to treat viral infections (medicines for viral infections).

Popular Brands prescribed for Viral Infections

BrandCompanyCompositionPack
ACIVIRCIPLAACICLOVIRBuy Acivir cream 5 gm(Acyclovir 5% w/w) Online at Best Price in India - Om  Health Cart
ZOVIRAXGSKACICLOVIRBuy Cold Sore Cream Tube 2 g by Zovirax Online | Priceline
OCUVIRFDCACICLOVIROcuvir 400 DT Tablet: View Uses, Side Effects, Price and Substitutes | 1mg
ATAZOR-REMCUREATAZANAVIR SULFATE + RITONAVIRAtazor R Tablets, Treatment: Anti Hiv, Packaging Type: Bottles, Rs 1600  /bottle | ID: 20229274555
INSTGRAEMCUREDOLUTEGRAVIR SODIUM SALTInstgra Dolutegravir Tablets, 30 Tablets, Rs 2950 /box Bull Pharmachem |  ID: 14530493533
VIROPILEMCUREDOLUTEGRAVIR SODIUM SALT + LAMIVUDINE + TENOFOVIR DISOPROXIL FUMARATEViropil Tablet, Packaging Type: Box, Rs 1200 /box Sar Agency | ID:  21114769573
VONAVIREMCUREEFAVIRENZ + EMTRICITABINE + TENOFOVIR DISOPROXIL FUMARATEVonavir, 30 Tabs In A Bottle, Rs 2700 /bottle Million Health  Pharmaceuticals | ID: 19892262873
VIRADAYCIPLAEFAVIRENZ + EMTRICITABINE + TENOFOVIR DISOPROXIL FUMARATEViraday Tablets, 30 Tablets, Rs 1300 /pack Goel Distributors | ID:  18567153033
VONADAYEMCUREEFAVIRENZ + LAMIVUDINE + TENOFOVIR DISOPROXIL FUMARATEEmcure Vonaday Tablets, Packaging Type: Packet, Rs 1400 /pack | ID:  19267452173
TENVIR-EMCIPLAEMTRICITABINE + TENOFOVIR DISOPROXIL FUMARATETenvir EM Tablet, 30 Tablets, Prescription, Rs 1150 /pack Saaransh Biotech  Private Limited | ID: 11011605488
TAVIN-EMEMCUREEMTRICITABINE + TENOFOVIR DISOPROXIL FUMARATETavin-Em Tenofovir Disoproxil Fumarate Tablet, Treatment: To Treat Hiv, 30  Tablets, Rs 2000 /pack | ID: 21056963248
ENTAVIRCIPLAENTECAVIREntecavir Tablet IP 0.5 mg Tablet at Rs 4200/box | Entecavir Tablet | ID:  10076924948
ENTALIVDRLENTECAVIREntaliv 0.5 mg Tablet (30 Tab): Price, Overview, Warnings, Precautions,  Side Effects & Substitutes - DR. REDDY'S LABS | SastaSundar.com
ENTEHEPZYDUS CADILAENTECAVIREntehep 0.5 Mg Tablet at Rs 600/strip | South Extension II | New Delhi| ID:  14160768330
ANTIFLUCIPLAOSELTAMIVIR PHOSPHATEAntiflu(Oseltamivir75mg), Cipla Ltd, Prescription, Rs 572 /strip | ID:  20652356912
FLUVIRHETERO HEALTHCAREOSELTAMIVIR PHOSPHATEFluvir 75mg Capsules at Rs 10/strip | Oseltamivir Phosphate, ओसेल्टामिविर -  S G Overseas, Surat | ID: 21868837855
SOVIHEPZYDUS CADILASOFOSBUVIRZydus Heptiza Sovihep 400mg Tablets, Packaging Size: 28 Tablets, Packaging  Type: Bottle, Rs 3000 /box | ID: 15493669497
MYHEPMYLAN PHARMASOFOSBUVIRMylan Sofosbuvir 400 MyHep, Rs 12000 /piece Palmary Life Sciences | ID:  20453799797
RESOFDRLSOFOSBUVIRDr Reddy's Laboratories Ltd Resof Total 400mg/100mg, Packaging Size: 28  Tablets, Rs 11000 /bottle | ID: 17181841355
MYHEP ALLMYLAN PHARMASOFOSBUVIR + VELPATASVIRMyhep All Tablet at Rs 8500/bottle | Hepcina, सोफोसबुविर - Global Care Lab,  Nagpur | ID: 17783630291
VELPANATNATCO PHARMASOFOSBUVIR + VELPATASVIRVelpanat Tablet, 28 Tablets, Treatment: Hepatitis C, Rs 8900 /bottle | ID:  20511827848
SOVIHEP VZYDUS CADILASOFOSBUVIR + VELPATASVIRSovihep V (Sofosbuvir 400mg Velpatasvir 100mg tablets), Hepcina, सोफोसबुविर  - Tissue Overseas, Surat | ID: 15523378673
VELPACLEARABBOTTSOFOSBUVIR + VELPATASVIRBuy Velpaclear Tablet 28's Online at Lowest Price From India
VELASOFHETERO HEALTHCARESOFOSBUVIR + VELPATASVIRVelasof Tablets, Hepcina, सोफोसबुविर - Tissue Overseas, Surat | ID:  15262921973
HEPCVELCIPLASOFOSBUVIR + VELPATASVIRSofosbuvir And Velpatasvir Hepcvel 400mg/100mg Tablets Sofosbuvir 400mg,  Velpatasvir100, 28 Tablet, Cipla Ltd, Rs 5000 /bottle | ID: 17111061555
HEPBESTMYLAN PHARMATENOFOVIR ALAFENAMIDE FUMARATEHepbest 25 Mg Tablets, टेनोफोविर अलफेनामाइड - Singhla Medicos, Delhi | ID:  21654906397
TENVIRCIPLATENOFOVIR DISOPROXIL FUMARATETenvir 300mg (Tenofovir Disoproxil Fumarate) Tablets, Prescription,  Treatment: Anti Hiv, Rs 900 /bottle | ID: 17428447688
VALCIVIRCIPLAVALACICLOVIR HYDROCHLORIDEValcivir Valaciclovir Tablet, 500 and 1000mg, Rs 135 /strip Care Exim | ID:  19024130012

References :

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