|Category of Drug||Antiviral Drugs|
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|Pharmacokinetic properties||1. The oral bioavailability – 10-20%; decreases with increasing doses.|
2. The bioavailability is not affected by food.
3. mean Tmax of 1.1±0.4 hours,
4. mean Cmax of 593.7-656.5ng/mL,
5. mean AUC of 2956.6-3102.5h*ng/mL
6. Vd- 0.6L/kg.
7. protein binding- 9-33%
|Mechanism of Action||It gets converted to acyclovir monophosphate by viral thymidine kinase and then undergoes a series of reactions by various enzymes to form acyclovir triphosphate. This form is more selective to the viral DNA polymerase than the cellular DNA and gets incorporated into the former resulting in viral DNA chain termination.|
|Indications|| Acyclovir is used for|
1. treatment of Herpes simplex keratitis
2. Long term suppression of skin infections in Herpes simplex as well as mucous membrane,
prophylaxis in immunocompromised patients
3. Herpes zoster treatment
| 1. Acivir-Cipla|
2. Zovirax- GSK
3. Ocuvir- FDC
|Available dosage forms||Tablets|
|Dose|| herpes simplex treatment: 200 mg five times daily usually for|
|Precautions|| 1. Maintain adequate hydration|
2. Monitor neutrophil count at least twice weekly in neonates
3. Renal impairment
5. not to be applied to the mucous membrane
|Adverse Effects|| 1. Nausea|
3. Abdominal pain
13. Neurological reactions
14. Acute renal failure
16. Thrombocytopenia and
|Storage condition||Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. |
Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
- National formulary
- pharmacokinetic properties
- storage condition
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