Pentazocine

Pentazocine- Popular brands, uses, and pharmacology

Pentazocine is an Opioid Analgesic. Pentazocine has agonist and antagonist activity against opiate receptors. It is a synthetic opioid, available in oral and parenteral forms as an analgesic for moderate-to-severe pain.

Pentazocine is used to treat moderate to severe pain. It is believed to work by activating κ-opioid receptors and blocking μ-opioid receptors. The major side effects are nausea, constipation, itching, drowsiness. Chemically it is benzomorphan, and it comes in two enantiomers, which are molecules that are exact (non-superimposable) mirror images of one another.

ParametersDescription
Category of DrugAgonist at the kappa and sigma opioid receptors
Mechanism of ActionPentazocine is an agonist at the κ-receptors and produces analgesia (1). It is believed to work by activating κ-opioid receptors and blocking μ-opioid receptors.
IndicationsPentazocine is used for
1. Moderate to severe pain
2. Pre-anaesthetic Medication
4. Colic
5. Trauma
6. Surgical procedures
7. Burns
Well Known
Pharmaceutical Brands
1. DOLOPENT- MODI
MUNDI PHARMA
2. FORTWIN- SUN
3. TAZOWIN- TAS MED
4. RIDDOF- NEON LABS
5. PENTAWOCK- WOCKHARDT
Available dosage forms 1. TABLETS
2. INJECTIONS
Storage conditionStore protected from light and moisture
DoseAdults: Pentazocine orally- 50 mg every 3 to 4 h; max. 600 mg daily
StructureThumb
Molecular detailsMolecular Formula- C19H27NO
Molecular Weight- 285.4 g/mol
IUPAC Name(1R,9R,13R)-1,13-dimethyl-10-(3-methylbut-2-enyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
Contraindications1. Patients dependent on opioids
2. Arterial or pulmonary hypertension
3. Heart failure
4. Narcotic dependence
5. Hypersensitivity
6. Ischaemia
7. Myocardial infarction.
Precautions1. Avoid in porphyria
2. Interactions
3. Impaired respiratory function
4. Pregnancy
5. Renal or hepatic function
Adverse Effects 1. Nausea
2. Vomiting
3. Euphoria
4. Sedation
5. Occasional Hallucinations.
Pregnancy Category C

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