Pentazocine is an Opioid Analgesic. Pentazocine has agonist and antagonist activity against opiate receptors. It is a synthetic opioid, available in oral and parenteral forms as an analgesic for moderate-to-severe pain.
Pentazocine is used to treat moderate to severe pain. It is believed to work by activating κ-opioid receptors and blocking μ-opioid receptors. The major side effects are nausea, constipation, itching, drowsiness. Chemically it is benzomorphan, and it comes in two enantiomers, which are molecules that are exact (non-superimposable) mirror images of one another.
| Parameters | Description |
|---|---|
| Category of Drug | Agonist at the kappa and sigma opioid receptors |
| Mechanism of Action | Pentazocine is an agonist at the κ-receptors and produces analgesia (1). It is believed to work by activating κ-opioid receptors and blocking μ-opioid receptors. |
| Indications | Pentazocine is used for 1. Moderate to severe pain 2. Pre-anaesthetic Medication 4. Colic 5. Trauma 6. Surgical procedures 7. Burns |
| Well Known Pharmaceutical Brands | 1. DOLOPENT- MODI MUNDI PHARMA 2. FORTWIN- SUN 3. TAZOWIN- TAS MED 4. RIDDOF- NEON LABS 5. PENTAWOCK- WOCKHARDT |
| Available dosage forms | 1. TABLETS 2. INJECTIONS |
| Storage condition | Store protected from light and moisture |
| Dose | Adults: Pentazocine orally- 50 mg every 3 to 4 h; max. 600 mg daily |
| Structure |  |
| Molecular details | Molecular Formula- C19H27NO Molecular Weight- 285.4 g/mol |
| IUPAC Name | (1R,9R,13R)-1,13-dimethyl-10-(3-methylbut-2-enyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol |
| Contraindications | 1. Patients dependent on opioids 2. Arterial or pulmonary hypertension 3. Heart failure 4. Narcotic dependence 5. Hypersensitivity 6. Ischaemia 7. Myocardial infarction. |
| Precautions | 1. Avoid in porphyria 2. Interactions 3. Impaired respiratory function 4. Pregnancy 5. Renal or hepatic function |
| Adverse Effects | 1. Nausea 2. Vomiting 3. Euphoria 4. Sedation 5. Occasional Hallucinations. |
| Pregnancy Category | C |
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