Warfarin

Warfarin- Indications, Dosage, Contraindications, ADRs

Category of Drug Warfarin is a Drug Affecting Coagulation
Mechanism of Action 
Indications Warfarin is used for
1. Prophylaxis of embolisation in rheumatic heart disease and atrial fibrillation
2. Prophylaxis after insertion of prosthetic heart valve
3. Prophylaxis and treatment of venous thrombosis and pulmonary embolism
4. Ischaemic attacks
5. Myocardial infarction
6. Valvular heart disease
Well Known
Pharmaceutical Brands
 
Available dosage forms TABLETS
Dose 
Contraindications 1. Pregnancy
2. Peptic ulcer
3. Severe hypertension
4. Bacterial endocarditis
5. Hypersensitivity
6. Blood dyscrasias
7. Recent surgery
8. Psychosis
9. Pericardial effusion
10. Cerebrovascular disorder
11. Alcoholism
12. Senility
13. Aneurysm
Precautions 1. Heparin-induced thrombocytopenia
2. Surgery or trauma
3. Vit C, K
4. lactation
5. Alcoholics
6. Purple toes syndrome
7. Discontinue if necrosis develops
8. Elderly
9. Hepatic impairment
10. Renal failure
11. Interactions
12. Lactation
Adverse Effects1. Haemorrhage
2. Hypersensitivity
3. rash
4. Alopecia
5. Diarrhoea
6. An unexplained drop in
haematocrit
7. skin necrosis
8. Jaundice
9. Hepatic dysfunction
10. Nausea
11. Voming and pancreatitis
Pregnancy Category X

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