| Parameters | details |
|---|---|
| Category of Drug | Topical fungicide. |
| Mechanism of Action | Tolnaftate is a topical fungicide that is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. The other reported action-: it distorts the hyphae and stunts mycelial growth in susceptible organisms. |
| Indications | Tolnaftate is used for 1. Ringworm infections 2. Athlete’s foot |
| Chemical Structure (1) |  |
| Molecular details | Molecular Formula- C19H17NOS Molecular Weight- 307.4 g/mol |
| IUPAC Name | O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate |
| Well Known Pharmaceutical Brands | 1. Tinaderm Lotion 20ml- Fulford India 2. Dermitop- Cadila 3. Cortec plus- Torrent |
| Available dosage forms | 1. CREAM 2. OINTMENT 3. SOLUTION |
| Dose | Apply to affected area BID (2) |
| Contraindications | 1. Hypersensitivity 2. Deep infections |
| Precautions | 1. Avoid contact with eyes and mucous membranes 2. Mixed infections 3. Discontinue if irritation occurs on application 4. Pregnancy |
| Adverse Effects | 1. Stinging 2. irritation 3. sensitization |
| Pregnancy Category | C |
