Tolnaftate- topical fungicide- Drug Profile

Category of DrugTopical fungicide.
Mechanism of ActionTolnaftate is a topical fungicide that is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. The other reported action-: it distorts the hyphae and stunts mycelial growth in susceptible organisms.
Indications Tolnaftate is used for
1. Ringworm infections
2. Athlete’s foot
Chemical Structure (1)Thumb
Molecular detailsMolecular Formula- C19H17NOS
Molecular Weight- 307.4 g/mol
IUPAC NameO-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
Well Known
Pharmaceutical Brands
1. Tinaderm Lotion 20ml- Fulford India
2. Dermitop- Cadila
3. Cortec plus- Torrent
Available dosage forms 1. CREAM
Dose Apply to affected area BID (2)
Contraindications1. Hypersensitivity
2. Deep infections
Precautions1. Avoid contact with eyes and mucous membranes
2. Mixed infections
3. Discontinue if irritation occurs on application
4. Pregnancy
Adverse Effects1. Stinging
2. irritation
3. sensitization
Pregnancy Category C

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