Mitomycin- Indications, Dosage, Contraindications, ADRs

Category of Drug Mitomycin is Immunosuppressives Drug
Mechanism of Action 
Indications Mitomycin is used for
1. Adenocarcinoma
2. Lymphosarcoma and
3. Superficial bladder cancer
Well Known
Pharmaceutical Brands
Available dosage forms INJECTIONS
Contraindications 1. Pregnancy
2. Bone marrow depression
3. Severe anaemia
4. Thrombocytopenia
5. lactation
Precautions It causes delayed bone-marrow toxicity and therefore it is usually administered at 6-weekly
Adverse Effects 1. Prolonged use may result in permanent bone-marrow damage
2. It may also cause lung fibrosis and renal damage
3. Dyspnea
Pregnancy Category D

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