| Category of Drug | Methotrexate is Immunosuppressives Drug |
| Mechanism of Action | |
| Indications | Methotrexate is used for 1. Carcinoma of the breast 2. Head and neck and lung 3. Trophoblastic tumours 4. Acute lymphoblastic leukaemia 5. Meningeal leukaemia 6. Non-Hodgkin’s lymphomas 7. Advanced cases of mycosis fungoides 8. Non-metastatic osteosarcoma 9. Severe rheumatoid arthritis |
| Well Known Pharmaceutical Brands | |
| Available dosage forms | 1. TABLETS 2. INJECTION 3. VIALS 4. GEL |
| Dose | |
| Contraindications | 1. Severe renal and hepatic impairment 2. Alcohol liver disease 3. Severe leucopenia 4. Thrombocytopenia 5. Pregnancy 6. Lactation |
| Precautions | 1. Bone marrow depression 2. Renal 3. Hepatic impairment 4. Interactions |
| Adverse Effects | 1. CNS toxicity 2. Stomatitis 3. Hepatobiliary disorder 4. Fatigue |
| Pregnancy Category | X |
