Midazolam- Indications, Dosage, Contraindications, ADRs

Parameters Description
Category of DrugMidazolam is a drug for Anaesthesia
Mechanism of Action 1Midazolam increases the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), in the central nervous system.
Indications 2Midazolam is used for
1. Intravenous sedative administered before or
during minor surgical procedures
2. Sedative administered by intravenous route in intensive
care induction of anesthesia
Structure 3Midazolam.png
Molecular details 1. Molecular Formula: C18H13ClFN3
2. Molecular Weight: 325.8 g/mol
IUPAC Name8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
Well Known
Pharmaceutical Brands
Available dosage forms INJECTION
Buy - Midazolam - Richmond - Ekinos.com
Dose 4Slow IV injection in adults- 2 mg/min; 5 to 10 min before procedure; initially 2 to 2.5 mg. Max. 7.5 mg)
Pharmacokinetic properties 1. Absorption: Rapidly absorbed after oral administration.
2. Volume of distribution: Female gender, old age, and obesity may increase the volume of distribution. 3. Protein binding: 97% bound to plasma protein.
4. Metabolism: Midazolam is primarily metabolized in the liver and gut by CYP3A4 
5. Half-life = 1.8 to 6.4 hours
Contraindications1. Acute narrow-angle glaucoma
2. Comatose patients
3. Shock
4. Acute alcohol intoxication
5. For intrathecal and epidural use
6. Acute pulmonary insufficiency
7. Myasthenia gravis
Precautions1. Chronic renal failure
2. Cardiac disease
3. Open-angle glaucoma
4. Respiratory disorders
5. Neonates
6. Prolonged use and abrupt
withdrawal should be avoided
7. Hepatic impairment
8. Pregnancy
Adverse Effects 1. Hypersensitivity
2. Cardiac arrest
3. Laryngospasm
4. Apnoea
5. Headache
6. Hiccups
7. Nausea
8. vomiting
9. Cough
10. Kernicterus
11. Nystagmus
Pregnancy Category D

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