Halothane- What are the Indications and side effects?

Parameters Description
Category of DrugHalothane is a drug for Anaesthesia
Mechanism of Action 1Halothane causes actions on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility.
Chemical structure 2Halothane.png
IUPAC Name2-bromo-2-chloro-1,1,1-trifluoroethane
Molecular details 1. Molecular Formula:- BrClHC2F3 or C2HBrClF3
2. Molecular Weight: 197.38 g/mol
Pharmacokinetic properties 11. Absorption-Not Available
2. The volume of distribution-Not Available
3. Protein binding-Not Available
4. Metabolism- Halothane is metabolized in the liver, primarily by CYP2E1
Indications Halothane is used for
1. Induction and maintenance of anaesthesia
Well Known
Pharmaceutical Brands
Hypnothane- Neon
Available dosage formsVolatile Liquid
Halothane: General Anesthetic agent - Gafacom (For health. For knowledge)
Dose Introductory dose: 0.5 to 3%.
Maintenance dose: 0.5 to 1.5%.
Contraindications 1. History of unexplained jaundice or pyrexia following previous exposure to halothane
2. Family history of malignant hyperthermia
3. Raised cerebrospinal fluid pressure
4. Porphyria
5. Not recommended for obstetrical anaesthesia
6. Interactions
Precautions 1. Anaesthetic history should be carefully taken to determine previous exposure and previous
reacons to halothane
2. Avoid for dental procedures
in patients under 18 years unless treated in hospital
3. Lactation
4. Renal failure
5. Hyperkalaemia
Adverse Effects1. Arrhythmias
2. Bradycardia
3. Respiratory depression
4. Hepatic damage
5. Malignant hyperthermia
6. Cyanosis
7. Post-operative nausea and voming
Pregnancy Category C

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