Etoposide- What are the Indications and side effects?

Category of DrugEtoposide is Immunosuppressives Drug
Mechanism of Action 1Etoposide inhibits DNA topoisomerase II, causing inhibition of DNA re-ligation. This interferes with DNA synthesis and can lead to apoptosis of the cancer cell.
Chemical Structure 2Etoposide.png
Molecular DetailsMolecular Formula: C29H32O13
Molecular Weight: 588.6 g/mol
IUPAC Name(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
IndicationsEtoposide is used for
1. Refractory testicular tumors
2. Acute leukemia
3. Malignant lymphoma
4. lung cancer
Well Known
Pharmaceutical Brands
 Posid- Cadila
Available dosage forms1. CAPSULES
Etoposide Injection - Prescriptiongiant
DoseAdult- Initially 50 to 100 mg/m2, body surface area daily by infusing over 30 to 60 min
Pharmacokinetic properties 1. Peak plasma concentration-1-1.5 hrs.
2. Mean bioavailability- 50% (range of 25% – 75%). 
3. Volume of distribution= 18 – 29 L.
4. Protein binding- 97%
5. Metabolism- 40% excreted unchanged in the urine
6. Half-life- 4-11 hours
Contraindications1. Hypersensitivity
2. Severe liver dysfunction
3. Pregnancy
4. lactation
Precautions1. Hepatic impairment
2. Interactions
3. Renal impairment
Adverse Effects 1. Alopecia
2. Gastrointestinal disturbances
3. Thrombophlebitis
4. Neuritis
Pregnancy Category D

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