Furazolidone

Furazolidone- Pharmacology and Popular Brands

Diarrhea can be explained as a frequent, often precipitate passage of poorly formed stools. The WHO defines the condition as 3 or more loose or watery stools in a period of 24-hours. Pathologically, it can be explained as a condition where the excess passage of water occurs in the feces. This article highlights the uses of Furazolidone for diarrhea.

Diarrhea can be a cause of 

  • Decreased electrolyte and water absorption
  • Increased secretion by the intestinal mucosa
  • Increased luminal osmotic load 
  • Inflammation of mucosa and exudation into the lumen.

The drugs used for such conditions are known as antidiarrheal drugs. Rational management for diarrhea treatment depends on investigating the underlying cause and prescribing drugs for specific therapy (if necessary).

Drug profile- Furazolidone

ParametersDetails
Category of DrugNitrofuran derivative
Mechanism of ActionFurazolidone works by killing bacteria and protozoa. It is used to treat bacterial and protozoal infections. Furazolidone binds with bacterial DNA, causing gradual inhibition of monoamine oxidase.
IndicationsFurazolidone is used for
1. Giardiasis
2. Cholera
3. Gastrointestinal infections
4. Protozoal or bacterial diarrhea and enteritis
5. Food poisoning
Video ExplainerWhat is diarrhea?
Well Known
Pharmaceutical Brands
1. METROGYL-F- UNIQUE PHARM
2. ENTROMAX- MANKIND
Available dosage forms1. TABLETS
2. CAPSULE
3. SUSPENSION
Buy Furoxone, Furazolidone Tablet ( Furoxone ) Online
Dose 100 mg 3 to 4 times a day.
StructureThumb
Molecular details1. Molecular Formula- C8H7N3O5
2. Molecular Weight-225.16 g/mol
IUPAC Name3-[(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one
Contraindications1. Hypersensitivity
2. Alcoholics
3. Primaquine sensitivity
Precautions 1. Urine colour changes to yellow after
administration
2. Orthostatic hypotension
3. Hypoglycaemia
4. Pregnancy
5. Interactions
Adverse Effects 1. Nausea
2. Vomiting
3. Constipation
4. Headache
5. Diarrhoea
6. Urticaria
7. Dyspnea
8. Dizziness
Pregnancy Category C

References:

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