Diarrhea can be explained as a frequent, often precipitate passage of poorly formed stools. The WHO defines the condition as 3 or more loose or watery stools in a period of 24-hours. Pathologically, it can be explained as a condition where the excess passage of water occurs in the feces. This article highlights the uses of Codeine for diarrhea.
Diarrhea can be a cause of
- Decreased electrolyte and water absorption
- Increased secretion by the intestinal mucosa
- Increased luminal osmotic load
- Inflammation of mucosa and exudation into the lumen.
The drugs used for such conditions are known as antidiarrheal drugs.
Drug profile- Codeine for diarrhea
|Category of Drug||An Opioid.|
|Mechanism of Action||Codeine is an Opioid that has agonist actions on the intestinal opioid receptors, which when activated cause constipation.|
|Indications|| Codeine is used for|
1. Short-term symptomatic relief of acute diarrhea in adults.
|Video explainer||What is diarrhea?|
|Codeine is mostly available in combination therapy.|
|Available dosage forms||Codeine for diarrhea is available in tablet form.|
|Dose||Codeine for diarrhea- 30 mg 3 to 4 times daily, in adult- for Symptomatic relief.|
|Molecular details||Molecular Formula- C18H21NO3|
Molecular Weight- 299.4 g/mol (2)
|Contraindications|| 1. Conditions where inhibition of peristalsis should be avoided|
2. Abdominal distension
3. Acute diarrhoeal conditions
4. Acute respiratory depression
|Precautions|| 1. Tolerance or dependence may occur with|
2. Elderly and debilitated patients
3. Hepatic impairment
4. Renal impairment
|Adverse Effects||1. Nausea|
5. Respiratory depression and hypotension
7. Difficulty with micturition
8. Ureteric or biliary spasm
9. Dry mouth