Flumazenil-Antidote Indications, Dosage, Contraindications, ADRs

Category of Drug Flumazenil-Antidote is Antidotes and Substances Used in Poisoning.
Mechanism of Action 
Indications Flumazenil-Antidote is used for
1. The antidote for benzodiazepine overdose
2. Reversal of sedative effects produced by benzodiazepines administered during general anaesthesia or diagnostic or
therapeutic procedures
Well Known
Pharmaceutical Brands
Available dosage forms INJECTION
Contraindications1. Epilepsy
2. Neuromuscular blockade
3. Hypersensitivity to benzodiazepines
4. Patients of suspected tricyclic antidepressant overdose
5. Raised intracranial pressure.
Precautions1. History of seizures
2. Panic attack
3. Alcohol drug dependence
4. Bleeding disorder
5. Liver disease
6. Head injury
7. Respiratory depression
8. Pregnancy
Adverse Effects1. Convulsions
2. Fatigue
3. Injection site pains
4. Increased sweating
5. Facial erythema
6. Raised intracranial pressure
7. Agitation
8. Dizziness
9. Abnormal vision
10. may cause complete heart
11. Flushing
12. Transient increase in blood
pressure and heart rate
Pregnancy Category C

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