Diarrhea can be explained as a frequent, often precipitate passage of poorly formed stools. The WHO defines the condition as 3 or more loose or watery stools in a period of 24-hours. Pathologically, it can be explained as a condition where the excess passage of water occurs in the feces. This article highlights the uses of Codeine for diarrhea.
Diarrhea can be a cause of
- Decreased electrolyte and water absorption
- Increased secretion by the intestinal mucosa
- Increased luminal osmotic load
- Inflammation of mucosa and exudation into the lumen.
The drugs used for such conditions are known as antidiarrheal drugs.
Drug profile- Codeine for diarrhea
| Parameters | Details |
|---|---|
| Category of Drug | An Opioid. |
| Mechanism of Action | Codeine is an Opioid that has agonist actions on the intestinal opioid receptors, which when activated cause constipation. |
| Indications | Codeine is used for 1. Short-term symptomatic relief of acute diarrhea in adults. 2. Pain |
| Video explainer | What is diarrhea? |
| Well Known Pharmaceutical Brands | Codeine is mostly available in combination therapy. |
| Available dosage forms | Codeine for diarrhea is available in tablet form. |
| Dose | Codeine for diarrhea- 30 mg 3 to 4 times daily, in adult- for Symptomatic relief. |
| Structure |  |
| IUPAC Name | (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol |
| Molecular details | Molecular Formula- C18H21NO3 Molecular Weight- 299.4 g/mol (2) |
| Contraindications | 1. Conditions where inhibition of peristalsis should be avoided 2. Abdominal distension 3. Acute diarrhoeal conditions 4. Acute respiratory depression |
| Precautions | 1. Tolerance or dependence may occur with prolonged use 2. Elderly and debilitated patients 3. Hepatic impairment 4. Renal impairment 5. Lactation 6. Overdosage 7. Pregnancy 8. Interactions |
| Adverse Effects | 1. Nausea 2. Vomiting 3. Constipation 4. Drowsiness 5. Respiratory depression and hypotension 6. Dependence 7. Difficulty with micturition 8. Ureteric or biliary spasm 9. Dry mouth 10. Sweating 11. Headache 12. Facial 13. Flushing 14. Vertigo |
| Pregnancy Category | C |
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