Atorvastatin- What are the indications, and popular brands?

Pfizer Lipid Regulating Agent Lipitor Atorvastatin Tablets, Rs 46872 /pack | ID: 21558985073

Parameters	Description
Category of Drug	Atorvastatin is Lipid-Lowering Drug. Read more: Which are the popular Medicines prescribed for Heart Disorders?
Structure
IUPAC Name	(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
Molecular details	Mol formula- C₃₃H₃₅FN₂O₅ Molecular weight- 558.6 g/mol
Mechanism of Action	Atorvastatin competitively inhibits HMG-CoA reductase (3-hydroxy-2-methylglutaryl Coenzyme A) enzyme and prevents the conversion of HMGCoA to mevalonate. It also enhances the uptake of low-density lipoproteins (LDL) in the liver by upregulating the LDL receptors. It also elicits its action by reducing the very low-density lipoproteins- cholesterol, serum triglycerides, and intermediate-density lipoproteins.
Indications	Atorvastatin is used for 1. Primary and secondary hypercholesterolemia 2. Prevention of cerebrovascular accidents 3. Primary prevention of coronary heart disease
Well Known Pharmaceutical Brands	ATOCOR- DRL ATORLIP- CIPLA ATORVA- ZYDUS CADILA AZTOR- SUN LIPICURE- INTAS STATOR- ABBOTT STORVAS-SUN TONACT- LUPIN
Available dosage forms	TABLETS
Dose	Adult- 10 mg daily, increased at 4 weeks interval. Max dose 80 mg.
Contraindications	1. Hypersensitivity 2. Active liver diseases or unexplained persistent elevation of serum transaminase 3. Pregnancy 4. lactation
Precautions	1. Patients who consume substantial quantities of alcohol and have a history of liver diseases 2. Children below 10 years 3. premenarcheal females 4. Interactions
Adverse Effects	1. Myopathy is a serious adverse effect 2. Headache 3. Infrequent elevation of creatinine phosphokinase 4. Rhabdomyolysis 5. Insomnia 6. Dizziness 7. Abdominal pain 8. Constipation 9. Diarrhoea 10. Dyspepsia
Pregnancy Category	X