Acetazolamide- Ophthalmic preparation for Glaucoma

Category of DrugAcetazolamide is an Ophthalmological Preparation drug
Mechanism of ActionAcetazolamide causes inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. Acetazolamide thus reduces intra-ocular pressure.
Indications Acetazolamide is used
1. As an adjunct in the treatment of chronic open-angle glaucoma
2. Secondary glaucoma
3. As part of the pre-operative treatment of acute angle-closure glaucoma
Chemical Structure 3Acetazolamide.png
IUPAC NameN-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
Molecular details Weight: 222.245
Chemical Formula- C4H6N4O3S2
Pharmacokinetic properties 2Absorption-Not Available
Volume of distribution- Not Available
Protein binding- 98%
Metabolism- Not Available
Route of elimination- Not Available
Half-life-3 to 9 hours
Well Known
Pharmaceutical Brands
1. Diamox- Sun
2. Iopar- FDC
Available dosage forms 1. TABLET
Acetazolamide - Care Online Pharmacy
DoseAdult- 0.25 to 1 gm daily in divided doses
Contraindications 1. Hypersensitivity to sulfonamides
2. Chronic angle-closure glaucoma
3. Hypokalaemia
4. Hyponatraemia
5. Hyperchloraemic acidosis
6. Renal impairment
7. Severe hepatic impairment
8. Renal hyperchloremic acidosis
9. Addison’s disease
Precautions1. Elderly
2. lactation
3. Diabetes Mellitus
4. Pulmonary obstruction
5. Monitor blood count and electrolytes if used for long
6. Interactions
7. Pregnancy
Adverse Effects1. Nausea
2. Vomiting
3. Diarrhoea
4. Taste disturbance
5. loss of appetite
6. Paraesthesia
7. Flushing
8. Headache
9. Dizziness
10. Fatigue
11. Irritability
12. Renal calculi
13. Blood disorders including agranulocytosis and
14. Rashes including Stevens-
Johnson syndrome and toxic epidermal necrolysis
Pregnancy Category C

Other Ophthalmic preparation

  • betaxolol
  • Clonidine
  • Latanoprost
  • Physostigmine
  • Pilocarpine
  • Timolol

2 thoughts on “Acetazolamide- Ophthalmic preparation for Glaucoma”

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