Central Nervous System: brain and its parts
The brain is one of the largest and most complex organs of the human body. It is the central organ of the nervous system, and along with the spinal cord, it makes up the central nervous system. Read more about CNS.
Antiemetics and types of antiemetics
Antiemetics are drugs effective against nausea and vomiting.
They are typically used to treat motion sickness. Antiemetics act on the brain by preventing the stimulation of the vomiting center (chemoreceptor trigger zone-CTZ). Examples
Classification: types of antiemetics
- 5-HT3 receptor antagonists- Ondansetron, Granisetron, Dolasetron, etc.
- Dopamine D2-receptor antagonists: Domperidone, Metoclopramide, Mosapride, etc.
- Antihistamines or H1- histamine receptor antagonists: Diphenhydramine, Promethazine, etc.
- Anticholinergics: Scopolamine, Hyoscine, Dicyclomine, etc.
Ondansetron is an Antiemetic prescribed for nausea and vomiting. Antiemetics treat motion sickness, chemotherapy-induced nausea and vomiting, and the side effects of general anesthetics and opioid analgesics.
Domperidone is a specific blocker of dopamine receptors. The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level.
Metoclopramide is Dopamine D2-receptor antagonists. It acts by inhibiting dopamine D2 and serotonin 5-HT3 receptors in the chemoreceptor trigger zone (CTZ), and causes antiemetic effects
Promethazine is a direct antagonist at the mesolimbic dopamine receptors and alpha-adrenergic receptors in the brain.
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