Amikacin- Indications, Dosage, and popular Brands

Parameters	Description
Category of Drug	Anti-Infectives Read more: Which are the popular antibiotics prescribed for infections?
Mechanism of Action	As an aminoglycoside, Amikacin binds to bacterial 30S ribosomal subunits and interferes with mRNA binding and tRNA acceptor sites, interfering with bacterial growth.
Indications	Amikacin is used in the short-term treatment of bacterial infections due to Gram-negative bacteria, including Pseudomonas species, Escherichia coli, Klebsiella, Enterobacter, Serratia species
Well Known Pharmaceutical Brands	1. Omnikacin-Cipla 2. Mikastar- Mankind 3. Mikacin- Aristo 4. Mik- Galpha Labs 5. Macmika- Macleods 6. La-Mika- Emcure 7. Amitax- Alkem 8. Amikamac- Macleods 9. Amiject- Alkem 10. Amicin- Zydus Cadila 11. Alinfec- Abbott 12. Alfakim- Sun
Available dosage forms	INJECTION
Dose	Adult- 15 mg/kg body weight daily in two divided doses (max 1.5g daily for 10 days, max. cumulative dose is 15g).
Contraindications	Myasthenia gravis hypersensitivity
Precautions	Pregnancy, renal impairment neonates, infants, and elderly; cross allergenicity
Adverse Effects	nephrotoxicity antibiotic-associated colitis stomatitis nausea, vomiting, rash
Pregnancy Category	D

References: