Parameters | Description |
---|---|
Category of Drug | Anti-Infectives Read more: Which are the popular antibiotics prescribed for infections? |
Mechanism of Action | As an aminoglycoside, Amikacin binds to bacterial 30S ribosomal subunits and interferes with mRNA binding and tRNA acceptor sites, interfering with bacterial growth. |
Indications | Amikacin is used in the short-term treatment of bacterial infections due to Gram-negative bacteria, including Pseudomonas species, Escherichia coli, Klebsiella, Enterobacter, Serratia species |
Well Known Pharmaceutical Brands | 1. Omnikacin-Cipla 2. Mikastar- Mankind 3. Mikacin- Aristo 4. Mik- Galpha Labs 5. Macmika- Macleods 6. La-Mika- Emcure 7. Amitax- Alkem 8. Amikamac- Macleods 9. Amiject- Alkem 10. Amicin- Zydus Cadila 11. Alinfec- Abbott 12. Alfakim- Sun |
Available dosage forms | INJECTION ![]() |
Dose | Adult- 15 mg/kg body weight daily in two divided doses (max 1.5g daily for 10 days, max. cumulative dose is 15g). |
Contraindications | Myasthenia gravis hypersensitivity |
Precautions | Pregnancy, renal impairment neonates, infants, and elderly; cross allergenicity |
Adverse Effects | nephrotoxicity antibiotic-associated colitis stomatitis nausea, vomiting, rash |
Pregnancy Category | D |
References:
- National Formulary
- Drug profile
- Dosage form
- MOA
- Warning
- Posology and method of administration
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