Xylometazoline- Indications, and popular brands

Name of the drugXylometazoline
Chemical structureXylometazoline.png
IUPAC Name2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
Other namesxylometazoline
Category of DrugXylometazoline is an Ophthalmological Preparations drug
Read more: Which are the popular Medicines for the Eyes?
Mechanism of ActionXylometazoline, a sympathomimetic, is a direct-acting drug. It acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa, causing vasoconstriction. In turn, the result is a decrease in blood flow in the nasal passages, relieving nasal congestion.
Indications Xylometazoline is used for
1. Nasal congestion
2. Conjunctival decongestant
Well Known
Pharmaceutical Brands

1.       Xylomist- Zydus Cadila
2.       Xyloflo- Lupin
3.       Otrivin- GSK
4.       Otrinoz-Old-GSK
5.       Nosikind- Mankind
Available dosage forms DROPS
Amazon.com: OTRIVINE Adult Nasal Spray 10 ml: Health & Personal Care
Contraindications 1. Narrow-angle glaucoma
2. Atrophic rhinitis
3. Vasomotor rhinitis
Precautions1. Avoid excessive or prolonged use
2. Caution in infants under 3 months
3. Infants and cardiac patients
4. Pregnancy
Adverse Effects 1. Local irritation
2. Nausea
3. Headache
4. After excessive use tolerance with a diminished effect
5. Rebound congestion
6. Cardiovascular effects
7. Dryness of eye and
8. Rhinitis medicaments
Pregnancy Category C


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