| Parameters | Details |
|---|---|
| Name of the drug | Xylometazoline |
| Chemical structure |  |
| IUPAC Name | 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole |
| Other names | xylometazoline Xylomethazoline Otrivine |
| Category of Drug | Xylometazoline is an Ophthalmological Preparations drug Read more: Which are the popular Medicines for the Eyes? |
| Mechanism of Action | Xylometazoline, a sympathomimetic, is a direct-acting drug. It acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa, causing vasoconstriction. In turn, the result is a decrease in blood flow in the nasal passages, relieving nasal congestion. |
| Indications | Xylometazoline is used for 1. Nasal congestion 2. Conjunctival decongestant |
| Well Known Pharmaceutical Brands | 1. Xylomist- Zydus Cadila 2. Xyloflo- Lupin 3. Otrivin- GSK 4. Otrinoz-Old-GSK 5. Nosikind- Mankind |
| Available dosage forms | DROPS |
| Dose | |
| Contraindications | 1. Narrow-angle glaucoma 2. Atrophic rhinitis 3. Vasomotor rhinitis |
| Precautions | 1. Avoid excessive or prolonged use 2. Caution in infants under 3 months 3. Infants and cardiac patients 4. Pregnancy |
| Adverse Effects | 1. Local irritation 2. Nausea 3. Headache 4. After excessive use tolerance with a diminished effect 5. Rebound congestion 6. Cardiovascular effects 7. Dryness of eye and nose 8. Rhinitis medicaments |
| Pregnancy Category | C |
References
- National Formulary
- Chemical properties
- MOA
- Clinical uses
- Wikipedia
- Other relevant details