Thiopental- Indications, Dosage, Contraindications, ADRs

Category of Drug Thiopental is a drug for Anaesthesia
Mechanism of Action 
Indications Thiopental is used for
1. Induction of anaesthesia prior to
administration of inhalational anaesthetic
2. anaesthesia of short duration 3. Preferred if cerebral ischemia is expected
Well Known
Pharmaceutical Brands
Available dosage forms STERILE POWDER
Contraindications 1. Inability to maintain airway
2. Hypersensitivity to barbiturates
3. Cardiovascular disease
4. Dyspnoea or obstructive respiratory disease
5. Porphyria
6. Hypotension or shock
7. Addison’s disease
8. Hepatic or renal dysfunction
9. Increased blood urea
Precautions 1. Local extravasation can result in extensive tissue necrosis and sloughing
2. Intra-arterial injection causes intense pain and may result in artery spasm
3. Hepatic impairment
4. Interactions
5. Patients with advanced cardiac disease
6. Increased intracranial pressure
7. Asthma
8. Myasthenia Gravis
9. Endocrine insufficiency
Adverse Effects1. Respiratory depression
2. Myocardial depression
3. Cardiac arrhythmias
4. Somnolence
5. Bronchospasm
6. urticaria
7. Vasodilation
8. Apnoea
9. Emergence delirium
10. Headache
11. Nausea
12. Oedema
Pregnancy Category C

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