| Category of Drug | Streptokinase is an Antithrombotic Drug |
| Mechanism of Action | |
| Indications | Streptokinase is used for 1. Life-threatening deep-vein thrombosis 2. Pulmonary embolism 3. Acute arterial thromboembolism 4. Thrombosed arteriovenous shunts 5. Acute myocardial infarction |
| Well Known Pharmaceutical Brands | |
| Available dosage forms | INJECTION |
| Dose | |
| Contraindications | 1. Recent haemorrhage 2. Surgery 3. Parturition 4. Trauma 5. Heavy vaginal bleeding 6. Haemorrhagic stroke 7. History of cerebrovascular disease 8. Coma 9. Severe hypertension 10. Coagulation defects 11. Bleeding diatheses 12. Aortic dissection 13. Risk of gastrointestinal bleeding 14. Acute pancreatitis 15. Severe liver disease 16. Acute pulmonary disease with cavitation |
| Precautions | 1. Risk of bleeding from any invasive procedure 2. External chest compression 3. Abdominal aneurysm or where thrombolysis may give rise to embolic complications such as enlarged le atrium with atrial fibrillation 4. Diabetic renopathy 5. Recent or concurrent anticoagulant treatment |
| Adverse Effects | 1. Nausea and vomiting 2. Bleeding 3. usually limited to the site of injection but internal bleeding including intracranial haemorrhage may occur 4. Hypotension 5. Arrhythmias 6. Allergic reactions 7. Back or abdominal pain 8. Guillain-Barré syndrome reported rarely |
| Pregnancy Category | C |
