Streptokinase- Indications, Dosage, Contraindications, ADRs

Category of DrugStreptokinase is an Antithrombotic Drug
Mechanism of Action 
Indications Streptokinase is used for
1. Life-threatening deep-vein thrombosis
2. Pulmonary embolism
3. Acute arterial thromboembolism
4. Thrombosed arteriovenous
5. Acute myocardial infarction
Well Known
Pharmaceutical Brands
Available dosage forms INJECTION
Contraindications 1. Recent haemorrhage
2. Surgery
3. Parturition
4. Trauma
5. Heavy vaginal bleeding
6. Haemorrhagic stroke
7. History of cerebrovascular disease
8. Coma
9. Severe hypertension
10. Coagulation defects
11. Bleeding diatheses
12. Aortic dissection
13. Risk of gastrointestinal bleeding
14. Acute pancreatitis
15. Severe liver disease
16. Acute pulmonary disease
with cavitation
Precautions 1. Risk of bleeding from any invasive procedure
2. External chest compression
3. Abdominal aneurysm or where thrombolysis may give rise to embolic complications such as enlarged le atrium with atrial
4. Diabetic renopathy
5. Recent or concurrent anticoagulant treatment
Adverse Effects 1. Nausea and vomiting
2. Bleeding
3. usually limited to the site of injection but internal
bleeding including intracranial haemorrhage may occur
4. Hypotension
5. Arrhythmias
6. Allergic reactions
7. Back or abdominal pain
8. Guillain-Barré syndrome
reported rarely
Pregnancy Category C

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