Sodium Nitroprusside

Sodium Nitroprusside- Indications, Dosage, Contraindications, ADRs

Category of Drug Sodium Nitroprusside is Antihypertensive Drugs
Mechanism of Action 
Indications Sodium Nitroprusside is used for
1. Hypertensive crisis
2. Congestive heart failure
Well Known
Pharmaceutical Brands
Available dosage forms INJECTION
Contraindications 1. Compensatory hypertension
2. Severe vitamin B12 deficiency
3. Leber optic atrophy
4. Arterial-venous shunting
5. Patients with acute CHF
associated with reduced peripheral vascular
Precautions1. Impaired pulmonary function
2. Hypothyroidism
3. Renal impairment
4. Ischaemic heart disease
5. Impaired cerebral circulation
6. Hyponatraemia
7. Raised intracranial pressure
8. Elderly
9. Hypothermia
10. Monitor blood pressure
11. Blood-cyanide concentration
Adverse Effects 1. Severe hypotension
2. Effects associated
with an over-rapid reduction in blood pressure include headache
3. Dizziness
4. Retching
5. Abdominal pain
6. Perspiration
7. Palpitations
8. Apprehension
9. Retrosternal discomfort
10. Muscle twitching
11. Hypothyroidism
12.Increased anaerobic metabolism
Pregnancy Category C

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