Pralidoxime (2-PAM)-Antidote- Indications, Dosage, Contraindications, ADRs

Category of Drug Pralidoxime (2-PAM)-Antidote is Antidotes and Substances Used in Poisoning.
Mechanism of Action 
Indications Pralidoxime (2-PAM)-Antidote is used for
1. Adjunct to atropine in the treatment of organophosphate poisoning and anticholinesterase overdosage used in the treatment of myasthenia gravis (mg)
2. Respiratory depression or severe muscle weakness due to carbamate poisoning
Well Known
Pharmaceutical Brands
Available dosage forms INJECTION
Contraindications1. Carbamate poisoning and organophosphates
without anticholinesterase activity
2. Hypersensitivity to the drug
Precautions 1. Impaired renal function
2. large doses can cause neuromuscular blockade
3. Myasthenia gravis
4. Atropinizaon occur faster on
concurrent use with atropine
5. Paediatrics
6. Allergies
7. Pregnancy
Adverse Effects1. Headache
2. Nausea
3. Blurred vision
4. Drowsiness
5. Dizziness
6. impaired accommodation
7. Tachycardia
8. Hyperventilation
9. Muscular weakness
10. Transient elevation in SGOT
11. SGPT levels
12. Laryngospasm and rigidity.
Pregnancy Category C

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