Losartan

Losartan- What are the indications, and popular brands?

ParameterDescription
Category of DrugLosartan is an angiotensin II receptor blocker (ARB). Read more: Which are the popular Medicines prescribed for Heart Disorders?
Losartan.png
Molecular detailsFormula- C22H23ClN6O
Molecular weight- 422.9 g/mol
IUPAC Name[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Mechanism of ActionLosartan and its 5-carboxylic acid metabolite selectively inhibit angiotensin-II receptor type-1 (AT1) and reduces the end-organ responses to angiotensin-II. It antagonizes the release of aldosterone, reduces total peripheral resistance and cardiac venous return. These changes facilitate its use as an antihypertensive agent.
Indications Losartan is used for
1. Congestive heart failure
2. Hypertension
3. With left ventricular hypertrophy
5. Diabetic nephropathy in type II diabetes
Well Known
Pharmaceutical Brands
TOZAAR-TORRENT
COVANCE- SUN
LOSACAR-ZYDUS CADILA
LOSAKIND-MANKIND
LOSANORM-IPCA
LOSAR-TORRENT
LOSIUM- CADILA
LOSTAT-BLUE CROSS
OMNITAN- MACLEODS
REPACE-SUN
Available dosage forms TABLETS
Vivimed Life Sciences recalls losartan potassium tablets after detecting  impurity
Dose 50 mg PO once a day initially; may increase to up to 100 mg/day
Contraindications1. Hyperaldosteronism
2. Hypersensitivity
3. Pregnancy
4. lactation
Precautions 1. Pre-existing heart, liver or kidney diseases
2. Diabetes
3. lactation
4. Volume-depleted patients
5. Renal artery stenosis
6. Monitor serum potassium concentration
7. Elderly
8. Interactions
Adverse Effects 1. Abdominal pain
2. Edema
3. Palpitation
3. Back pain
4. Dizziness
5. Sinusitis
6. Upper respiratory tract infection
7. Gastrointestinal disturbances
8. Transient elevation of liver
enzymes
9. Impaired renal function
10. Taste disturbances
Pregnancy Category C

References

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