Hydrochlorthiazide

Hydrochlorothiazide: What are the indications and popular brands?

ParametersDescription
Category of DrugHydrochlorothiazide is a thiazide diuretic.
Read More: Which are the popular Medicines prescribed for Heart Disorders?
Structure 1Hydrochlorothiazide.png
Molecular details 1
Mol formula- C7H8ClN3O4S2
Mol weight- 297.7 g/mol
IUPAC Name 16-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
Mechanism of ActionHydrochlorothiazide is a thiazide diuretic that acts on the distal convoluted tubule by inhibiting the reabsorption by the sodium-chloride symporter. This in turn reduces the difference in concentration gradient between the epithelial cells and the distal convoluted tubule and thereby prevents reabsorption of water.
Indications 1. monotherapy in-mild hypertension
2. combination therapy in- moderate to severe
hypertension; heart failure; edema; diabetes insipidus
Well Known
Pharmaceutical Brands
The following brands are the combination therapies of hydrochlorothiazide.

1. TRIPIN OM- LUPIN
2. TRIOLMIGHTY- MERCK
3. TRIOLMESAR- MACLEODS
4. TELVAS 3D- ARISTO
5. TELMIKIND-MANKIND
6. TAZLOC TRIO- USV
7. TAH- INTAS
8. CRESAR PLUS- CIPLA
Available dosage formsTABLETS
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Dose1. Hypertension: 12.5 to 25 mg daily.
2. Heart failure: Loading dose- 25 mg daily on waking
up, maintenance dose- 50 mg daily if necessary.
Contraindications1. Severe renal or severe hepatic impairment
2. hyponatremia
3. hypercalcemia
4. gout
5. anuria
6. sulphonamide allergy
Precautions1. Renal and hepatic impairment
2. lactation
3. porphyria; severe heart failure; edema; hyperlipidemia; interactions
4. pregnancy
Adverse Effects1. Fluid and electrolyte imbalance
2. weakness; lethargy; drowsiness; seizures; headache; muscle pains or cramps; hypotension
3. hypercalcemia; hyperglycemia;
hyperuricemia; gout; rash; photosensitivity
4. pancreatitis; intrahepatic cholestasis; acute
renal failure; hypersensitivity reactions
Pregnancy Category B

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