Category of Drug | Flucytosine is an Anti-Infectives |
Mechanism of Action | |
Indications | Flucytosine is used for 1. Adjunct to amphotericin B in cryptococcal meningitis 2. Adjunct to amphotericin B in systemic candidiasis 3. Septicemia 4. Pulmonary infection |
Well Known Pharmaceutical Brands | |
Available dosage forms | 1. CAPSULE 2. INFUSION |
Dose | |
Contraindications | 1. Renal impairment 2. Elderly 3. Blood disorders 4. Pregnancy 5. Hypersensitivity |
Precautions | 1. Elderly 2. Renal impairment 3. Also the use with amphotericin B 4. liver and kidney funcon tests and blood counts required 5. lactation 6. Interactions 7. Pregnancy |
Adverse Effects | 1. Rash 2. Vomiting 3. Nausea 4. Alterations in liver function tests 5. Less frequently, confusion, hallucinations, convulsions 6. Blood disorders including leukopenia 7. Potentially fatal thrombocytopenia and aplastic anaemia 8. Cardiac arrest |
Pregnancy Category | C |