Diazepam- Drug Detail Profile

Category of DrugDiazepam is an Anticonvulsants/Antiepileptics
Mechanism of Action 
Indications Diazepam is used for
1. Status epilepticus
2. Emergency management of recurrent seizures
3. Febrile convulsions
4. Seizures associated with poisoning and
medicine withdrawal
5. Adjunct in acute alcohol withdrawal
6. Premedication
7. Anxiety disorders
8. Psychosomatic behaviour disorder
9. Spasticity.
Well Known
Pharmaceutical Brands
Available dosage forms1. TABLETS
Contraindications1. Respiratory depression
2. Acute pulmonary
3. Insufficiency
4. Sleep apnoea
5. Severe hepatic impairment
6. Myasthenia Gravis
7. Avoid injections containing benzyl alcohol in neonates
8. Narrow-angle glaucoma
9. Hypersensitivity to benzodiazepine.
Precautions1. Respiratory disease
2. Muscle weakness
3. History of alcohol or drug abuse
4. Marked personality disorder
5. Pregnancy
6. lactation
9. Reduce dose in elderly or debilitated patients and in hepatic impairment
10. Renal impairment
11. Avoid prolonged use and abrupt withdrawal
12. when given intravenously
13. Facilities for reversing respiratory depression
Adverse Effects1. Drowsiness and lightheadedness the next
2. Confusion and ataxia
3. Amnesia
4. Dependence
5. Paradoxical increase in aggression
6. Muscle weakness
7. Occasionally headache
8. vertigo
9. salivation changes
10. Gastrointestinal disturbances
11. Visual disturbances
12. Dysarthria
13. urinary retention
14. blood disorders and jaundice
Pregnancy Category D

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