D-Penicillamine- Drug Detail Profile

Category of Drug D-Penicillamine is an Antidotes and Substances Used in Poisoning
Mechanism of Action 
Indications D-Penicillamine is used for
1. Poisoning by heavy metals
2. Particularly lead and copper
3. Wilson’s disease
4. Severe rheumatoid arthritis
Well Known
Pharmaceutical Brands
Available dosage forms CAPSULE/TABLET
Contraindications1. Hypersensitivity
2. Lupus erythematosus
3. Gold or antimalarial drug
4. Penicillamine-induced agranulocytosis
5. Aplastic anaemia
6. Pregnancy
7. lactation
Precautions 1. Monitor throughout treatment including
blood counts and urine tests
2. Renal impairment
3. Immunosuppressive treatment
4. Avoid oral iron within 2 h of a dose
5. Hepatic impairment
6. Pregnancy
Adverse Effects 1. Initially nausea
2. Anorexia
3. Fever
4. Taste loss
5. Blood disorders including thrombocytopenia
6. Neutropenia
7. Agranulocytosis and aplastic anaemia
8. Proteinuria
9. Haematuria
10. Haemolytic anaemia
11. Nephrotic syndrome
Pregnancy Category D

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