| Category of Drug | D-Penicillamine is an Antidotes and Substances Used in Poisoning |
| Mechanism of Action | |
| Indications | D-Penicillamine is used for 1. Poisoning by heavy metals 2. Particularly lead and copper 3. Wilson’s disease 4. Severe rheumatoid arthritis |
| Well Known Pharmaceutical Brands | |
| Available dosage forms | CAPSULE/TABLET |
| Dose | |
| Contraindications | 1. Hypersensitivity 2. Lupus erythematosus 3. Gold or antimalarial drug 4. Penicillamine-induced agranulocytosis 5. Aplastic anaemia 6. Pregnancy 7. lactation |
| Precautions | 1. Monitor throughout treatment including blood counts and urine tests 2. Renal impairment 3. Immunosuppressive treatment 4. Avoid oral iron within 2 h of a dose 5. Hepatic impairment 6. Pregnancy |
| Adverse Effects | 1. Initially nausea 2. Anorexia 3. Fever 4. Taste loss 5. Blood disorders including thrombocytopenia 6. Neutropenia 7. Agranulocytosis and aplastic anaemia 8. Proteinuria 9. Haematuria 10. Haemolytic anaemia 11. Nephrotic syndrome |
| Pregnancy Category | D |
