Cotrimoxazole- Drug Detail Profile

Category of Drug Cotrimoxazole is an Anti-Infective drug
Mechanism of Action 
Indications Cotrimoxazole is used for
1. Urinary-tract infections
2. Respiratory-tract infections
Well Known
Pharmaceutical Brands
Available dosage forms 1. TABLETS
Contraindications 1. Hypersensitivity to sulfonamides or
2. Porphyria
3. Marked liver parenchymal damage
4. Blood dyscrasias,
5. Severe renal insufficiency
Precautions1. Renal impairment
2. Hepatic impairment
3. Maintain adequate fluid intake
4. Avoid in blood disorders
5. Monitor blood counts and discontinue immediately if blood disorder develops
6. Rash-discontinue immediately
7. Predisposition to folate deficiency
8. Elderly
9. G-6-PD deficiency
10. lactation
11. Pregnancy
Adverse Effects 1.Nausea
2. Vomiting
3. Diarrhoea
4. Headache
5. Hypersensitivity reactions
6. photosensitivity
7. Serum sickness
8. Crystalluria-resulting in haematuria
9. oliguria
10. Anuria
11. Blood disorders including granulocytopenia
12. Aplastic anaemia
13. Purpura-discontinue immediately
14. Hallucinations and electrolyte disturbances
Pregnancy Category C

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